Novel synthesis of symmetrical dinitro and diamino Tr?ger's base analogues

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60461373%3A22310%2F12%3A43894882" target="_blank" >RIV/60461373:22310/12:43894882 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.1002/ejoc.201201188" target="_blank" >http://dx.doi.org/10.1002/ejoc.201201188</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1002/ejoc.201201188" target="_blank" >10.1002/ejoc.201201188</a>

Result language
angličtina
Original language name
Novel synthesis of symmetrical dinitro and diamino Tr?ger's base analogues
Original language description
This report describes new synthetic approach to symmetrical diamino Tr?ger's base analogues allowing synthesis of 1,7-, and 4,10-diamino derivatives with no additional substituents and 3,9-diamino derivative with methyl groups in the 1,4,7 and 10 positions. The synthesis uses regioselective nitration of the dihalogen or tetrahalogen Tr?ger's bases followed by hydrogenation of the nitro functions accompanied by removal of halogen atoms. Alternatively, chemoselective reduction of nitro groups can be usedto obtain the dihalogen diamino Tr?ger's base analogues. The 2,8-diamino derivatives, which are not accessible using this approach, can be prepared by Buchwald-Hartwig amination of the 2,8-dibromo Tr?ger's bases.
Czech name
—
Czech description
—

Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
CC - Organic chemistry
OECD FORD branch
—

Publication year
2012
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Similar results(10)