Effect of dirty-hold time on cleaning process of pharmaceutical equipment
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60461373%3A22310%2F13%3A43896478" target="_blank" >RIV/60461373:22310/13:43896478 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.3109/10837450.2012.726997" target="_blank" >http://dx.doi.org/10.3109/10837450.2012.726997</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.3109/10837450.2012.726997" target="_blank" >10.3109/10837450.2012.726997</a>
Alternative languages
Result language
angličtina
Original language name
Effect of dirty-hold time on cleaning process of pharmaceutical equipment
Original language description
The work was aimed at the evaluation of a cleanliness of pharmaceutical equipments after the end of the production and subsequent cleaning process. The influence of a dirty-hold time, a time interval between the end of the production period and the beginning of the cleaning process on its efficiency and the cleanliness of the equipment has been studied. The evaluation was performed for commercial tablet antihypertensive formulation with API losartan potassium. Sampling was carried out by a wet-swabbingmethod from the equipments and consequently obtained samples were analytically evaluated using HPLC. In the production of the concerned pharmaceutical, it has been found that the cleaning process is properly designed and validated. Despite the concentration of losartan in swabs from the equipment was in all cases within the limits of acceptance criteria, the effect of the dirty-hold time was proved. In the equipments with long hold-time period, the monitored substance was found in substa
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
CI - Industrial chemistry and chemical engineering
OECD FORD branch
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Result continuities
Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2013
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Pharmaceutical Development and Technology
ISSN
1083-7450
e-ISSN
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Volume of the periodical
18
Issue of the periodical within the volume
1
Country of publishing house
GB - UNITED KINGDOM
Number of pages
6
Pages from-to
274-279
UT code for WoS article
000312008200028
EID of the result in the Scopus database
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