Dirty-Hold Time Effect on the Cleaning Process Efficiency

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60461373%3A22310%2F12%3A43894830" target="_blank" >RIV/60461373:22310/12:43894830 - isvavai.cz</a>

Result on the web

<a href="http://www.sciencedirect.com/science/article/pii/S1877705812028342" target="_blank" >http://www.sciencedirect.com/science/article/pii/S1877705812028342</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.proeng.2012.07.434" target="_blank" >10.1016/j.proeng.2012.07.434</a>

Result language

angličtina

Original language name

Dirty-Hold Time Effect on the Cleaning Process Efficiency

Original language description

The paper evaluated the efficiency of a standard cleaning procedure of the process equipment after production of anti hypertensive with the active component Losartan Potassium for different lengths of time between completion of production and the start of the treatment process - so called dirty-hold time. It has been found that the cleaning process is appropriately designed and efficient. The concentration of losartan in swabs from the equipments was in all cases within the limits of acceptance criteria. However, the washing process was in all cases sufficiently effective to meet the eligibility criteria, significant effect of the time of weaning of the contaminated equipment on the efficiency of the washing process was found. At studied dirty hold time horizon (0-4 days) there was a progressive deterioration of the efficiency of the cleaning process. It was found that the influence of the nature of the residual material on the cleaning process has minor effect then the length of the d

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

CI - Industrial chemistry and chemical engineering

OECD FORD branch

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Project

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Continuities

Z - Vyzkumny zamer (s odkazem do CEZ)

Publication year

2012

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Procedia Engineering

ISSN

1877-7058

e-ISSN

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Volume of the periodical

42

Issue of the periodical within the volume

September

Country of publishing house

NL - THE KINGDOM OF THE NETHERLANDS

Number of pages

6

Pages from-to

431-436

UT code for WoS article

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EID of the result in the Scopus database

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