Effect of chain elongation on biological properties of the toxin paralysin beta-alanyl-tyrosine
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60461373%3A22310%2F14%3A43897357" target="_blank" >RIV/60461373:22310/14:43897357 - isvavai.cz</a>
Alternative codes found
RIV/60461373:22340/14:43897357 RIV/60461373:22330/14:43897357
Result on the web
<a href="http://dx.doi.org/10.1111/cbdd.12257" target="_blank" >http://dx.doi.org/10.1111/cbdd.12257</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1111/cbdd.12257" target="_blank" >10.1111/cbdd.12257</a>
Alternative languages
Result language
angličtina
Original language name
Effect of chain elongation on biological properties of the toxin paralysin beta-alanyl-tyrosine
Original language description
In haemolymph of insect species compounds with remarkable properties for pharmaceutical industry are present. At the first line there were found compounds of low molecular mass, less than 1 kDa. One of such compounds, beta-alanyl-tyrosine (252 Da), was isolated from larval haemolymph of some species of holometabolous insects (e.g. Neobellieria bullata). Its paralytic activity and antimicrobial properties were described until now. In this study we present the effect of elongation of beta-alanyl-tyrosineby repeating of this motive on the biological and physical properties of prepared analogs. For assessment of antimicrobial properties of these new compounds strains of Gram-positive, Gram-negative bacteria and fungi were used, we also followed the haemolytic activity and toxic effect on human cell culture HepG2. On the base of ECD spectroscopy measurement, subsequent molecular modeling and known secondary structure of original beta-alanyl-tyrosine dipeptide the secondary structures of re
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
CE - Biochemistry
OECD FORD branch
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Result continuities
Project
<a href="/en/project/GA522%2F09%2F1693" target="_blank" >GA522/09/1693: The role of antimicrobial peptides in plant defense against pahogenic microorganisms</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2014
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Chemical Biology & Drug Design
ISSN
1747-0285
e-ISSN
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Volume of the periodical
83
Issue of the periodical within the volume
4
Country of publishing house
US - UNITED STATES
Number of pages
9
Pages from-to
418-426
UT code for WoS article
000332886400005
EID of the result in the Scopus database
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