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Multimarker Screening of Oxidative Stress in Aging

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60461373%3A22310%2F14%3A43897435" target="_blank" >RIV/60461373:22310/14:43897435 - isvavai.cz</a>

  • Result on the web

    <a href="http://dx.doi.org/10.1155/2014/562860" target="_blank" >http://dx.doi.org/10.1155/2014/562860</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.1155/2014/562860" target="_blank" >10.1155/2014/562860</a>

Alternative languages

  • Result language

    angličtina

  • Original language name

    Multimarker Screening of Oxidative Stress in Aging

  • Original language description

    Aging is a complex process of organism decline in physiological functions. There is no clear theory explaining this phenomenon, but the most accepted one is the oxidative stress theory of aging. Biomarkers of oxidative stress, substances, which are formed during oxidative damage of phospholipids, proteins, and nucleic acids, are present in body fluids of diseased people as well as the healthy ones (in a physiological concentration). 8-iso prostaglandin F2? is themost prominent biomarker of phospholipidoxidative damage, o-tyrosine, 3-chlorotyrosine, and 3-nitrotyrosine are biomarkers of protein oxidative damage, and 8-hydroxy-2?-deoxyguanosine and 8-hydroxyguanosine are biomarkers of oxidative damage of nucleic acids. It is thought that the concentration of biomarkers increases as the age of people increases. However, the concentration of biomarkers in body fluids is very low and, therefore, it is necessary to use a sensitive analytical method. A combination of HPLC andMS was chosen to

  • Czech name

  • Czech description

Classification

  • Type

    J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

  • CEP classification

    CB - Analytical chemistry, separation

  • OECD FORD branch

Result continuities

  • Project

    Result was created during the realization of more than one project. More information in the Projects tab.

  • Continuities

    P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Others

  • Publication year

    2014

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    Oxidative Medicine and Cellular Longevity

  • ISSN

    1942-0994

  • e-ISSN

  • Volume of the periodical

    2014

  • Issue of the periodical within the volume

    ID 562860

  • Country of publishing house

    US - UNITED STATES

  • Number of pages

    14

  • Pages from-to

    1-14

  • UT code for WoS article

  • EID of the result in the Scopus database