Application and Comparison of Cocrystallization Techniques on Trospium Chloride Cocrystals

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60461373%3A22310%2F14%3A43897853" target="_blank" >RIV/60461373:22310/14:43897853 - isvavai.cz</a>

Alternative codes found

RIV/68378271:_____/14:00435103 RIV/60461373:22810/14:43897853

Result on the web

<a href="http://dx.doi.org/10.1021/cg500226z" target="_blank" >http://dx.doi.org/10.1021/cg500226z</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1021/cg500226z" target="_blank" >10.1021/cg500226z</a>

Result language

angličtina

Original language name

Application and Comparison of Cocrystallization Techniques on Trospium Chloride Cocrystals

Original language description

To identify as many solid forms of active pharmaceutical ingredient (API) as possible and to monitor their cocrystallization potential, synthetic methods are needed. According to API properties (solubility, melting point, stability), suitable screening methods have to be considered. In this study, the performance of most of the commonly available cocrystallization techniques such as neat grinding, liquid-assisted grinding, slurrying, co-melting, and slow evaporation was compared. We applied them to four pharmaceutical cocrystals of trospium chloride (TCl, a muscarinic antagonist urinary antispasmodic) with adipic (AD), glutaric (GA), oxalic (OX), and salicylic acids (SA), which were identified as hits from previous slow evaporation experiments. Their structures were determined by single-crystal X-ray diffraction (TCl-SA and TCl-OX cocrystals) or from powder X-ray diffraction data (TO-AD and TCl-GA cocrystals). Other methods to characterize the cocrystal phases were applied (H-1 NMR, DSC, IR, and Raman spectroscopy). Comparison of cocrystallization methods and of the prepared cocrystals was discussed.

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FR - Pharmacology and apothecary chemistry

OECD FORD branch

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Project

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Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2014

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Crystal Growth &amp; Design

ISSN

1528-7483

e-ISSN

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Volume of the periodical

14

Issue of the periodical within the volume

6

Country of publishing house

US - UNITED STATES

Number of pages

6

Pages from-to

2931-2936

UT code for WoS article

000337018900030

EID of the result in the Scopus database

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