Systematic solvate screening of trospium chloride: discovering hydrates of a long-established pharmaceutical

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60461373%3A22310%2F15%3A43899757" target="_blank" >RIV/60461373:22310/15:43899757 - isvavai.cz</a>
Alternative codes found
RIV/68378271:_____/15:00451553
Result on the web
<a href="http://dx.doi.org/10.1039/C5CE00744E" target="_blank" >http://dx.doi.org/10.1039/C5CE00744E</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1039/C5CE00744E" target="_blank" >10.1039/C5CE00744E</a>

Result language
angličtina
Original language name
Systematic solvate screening of trospium chloride: discovering hydrates of a long-established pharmaceutical
Original language description
The ability of the antispasmodic agent trospium chloride (TCl) to form solvates was investigated by applying conventional solvate screening methods on 20 solvents. According to the solubility of TCl, different approaches were considered (slow evaporation, slurrying and anti-solvent addition). Five solvates, with the solvents methanol, acetonitrile, propionitrile, N,N-dimethylformamide, nitromethane and dihydrate, were identified and characterized by various analytical techniques. Moreover, a solvate with isopropyl alcohol and TCl sesquihydrate was prepared circumstantially outside the systematic screening. The structures of all the solvates were determined by single crystal X-ray diffraction. The reproducible forms were further characterized by powder X-ray diffraction and desolvation behaviour was observed by thermoanalytical (TGA/DSC) methods. Structural features of novel solvates and of previously described polymorphs and cocrystals of TCl were compared, presented by a tree diagram which classifies the structures according to their molecular packing.
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FR - Pharmacology and apothecary chemistry
OECD FORD branch
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Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
S - Specificky vyzkum na vysokych skolach<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2015
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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