Polymethylmethacrylate doped with porphyrin and silver nanoparticles as light-activated antimicrobial material

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60461373%3A22310%2F14%3A43898003" target="_blank" >RIV/60461373:22310/14:43898003 - isvavai.cz</a>
Alternative codes found
RIV/60461373:22330/14:43898003 RIV/67985858:_____/14:00443176
Result on the web
<a href="http://dx.doi.org/10.1039/c4ra08385g" target="_blank" >http://dx.doi.org/10.1039/c4ra08385g</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1039/c4ra08385g" target="_blank" >10.1039/c4ra08385g</a>

Result language
angličtina
Original language name
Polymethylmethacrylate doped with porphyrin and silver nanoparticles as light-activated antimicrobial material
Original language description
Light-activated antimicrobial materials based on polymethylmethacrylate doped with porphyrin and silver nanoparticles were prepared and studied. The inspiration for the material design originates from photodynamic therapy where light is used to destroy pathogen microbes. Antimicrobial response of the materials is controlled by blue light illumination. Porphyrin molecules serve as light absorbers with dual antimicrobial response under illumination they produce reactive oxygen and affect the kinetics of silver release from the polymer. Silver is responsive for the antimicrobial effect, for the protection of porphyrin against photobleaching and for the conservation of energy through suppression of porphyrin luminescence. Triggerable and enhanced antimicrobial response of the material is activated through several possible mechanisms, including local heating of the polymer matrix, transfer of the excited state from porphyrin to silver and the synergetic effect of reactive oxygen and silver. In a passive state the material exhibits weak antimicrobial response against Gram-negative bacteria. In an active state, however, it is fatal for both Gram negative and Gram positive bacteria.
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
JJ - Other materials
OECD FORD branch
—

Project
<a href="/en/project/GBP108%2F12%2FG108" target="_blank" >GBP108/12/G108: Preparation, modification and characterization of materials by radiation</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year
2014
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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