Synthesis of Potentially Biologically Active 6-(1,3-Butadiynyl) purines

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60461373%3A22310%2F15%3A43900395" target="_blank" >RIV/60461373:22310/15:43900395 - isvavai.cz</a>
Result on the web
<a href="http://onlinelibrary.wiley.com/doi/10.1002/jhet.1938/full" target="_blank" >http://onlinelibrary.wiley.com/doi/10.1002/jhet.1938/full</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1002/jhet.1938" target="_blank" >10.1002/jhet.1938</a>

Result language
angličtina
Original language name
Synthesis of Potentially Biologically Active 6-(1,3-Butadiynyl) purines
Original language description
1,3-Alkadiynyl(trimethyl)silanes were prepared by the Negishi or Sonogashira reactions of bromoethynyl(trimethyl)silane with several terminal alkynes in 34-75% yield. However, the direct Hiyama coupling of these compounds with 6-iodopurine derivatives has not been successful. Therefore, a modified Sonogashira reaction using TBAF or CsF for in situ removal of the trimethylsilyl group has been utilized. This methodology afforded the desired 6-(1,3-butadiynyl)purines in 47-87% yield.
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
CC - Organic chemistry
OECD FORD branch
—

Project
<a href="/en/project/GA203%2F09%2F1552" target="_blank" >GA203/09/1552: Application of 7,8-Dihydropurines in the Synthesis of New Purine Derivatives with Potential Biological Activity</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year
2015
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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