Reward related neurotransmitter changes in a model of depression: An in vivo microdialysis study

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60461373%3A22310%2F15%3A43900478" target="_blank" >RIV/60461373:22310/15:43900478 - isvavai.cz</a>

Alternative codes found

RIV/00216224:14110/15:00084203 RIV/00216208:11120/15:43910324

Result on the web

<a href="http://dx.doi.org/10.3109/15622975.2015.1077991" target="_blank" >http://dx.doi.org/10.3109/15622975.2015.1077991</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.3109/15622975.2015.1077991" target="_blank" >10.3109/15622975.2015.1077991</a>

Result language

angličtina

Original language name

Reward related neurotransmitter changes in a model of depression: An in vivo microdialysis study

Original language description

Objectives: The self-medication hypothesis assumes that symptoms related to potential monoaminergic deficits in depression may be relieved by drug abuse. The aim of this study was to elucidate the neurotransmitter changes in a rat model of depression by measuring their levels in the nucleus accumbens shell, which is typically involved in the drug of abuse acquisition mechanism. Methods: Depression was modelled by the olfactory bulbectomy (OBX) in Wistar male rats. In vivo microdialysis was performed, starting from the baseline and following after a single methamphetamine injection and behaviour was monitored. The determination of neurotransmitters and their metabolites was performed by high-performance liquid chromatography combined with mass spectrometry. Results: OBX animals had lower basal levels of dopamine and serotonin and their metabolites. However, ?-aminobutyric acid (GABA) and glutamate levels were increased. The methamphetamine injection induced stronger dopamine and serotonin release in the OBX rats and lower release of glutamate in comparison with sham-operated rats; GABA levels did not differ significantly. Conclusions: This study provides an evidence of mesolimbic neurotransmitter changes in the rat model of depression which may elucidate mechanisms underlying intravenous self-administration studies in which OBX rats were demonstrated to have higher drug intake in comparison to intact controls.

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FH - Neurology, neuro-surgery, nuero-sciences

OECD FORD branch

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Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2015

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

World Journal of Biological Psychiatry

ISSN

1562-2975

e-ISSN

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Volume of the periodical

16

Issue of the periodical within the volume

7

Country of publishing house

GB - UNITED KINGDOM

Number of pages

16

Pages from-to

521-535

UT code for WoS article

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EID of the result in the Scopus database

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