Optimizing Flow And Segregation Properties Of Lactose/Microcrystalline Cellulose Mixture For Tablet Compression
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60461373%3A22310%2F15%3A43900680" target="_blank" >RIV/60461373:22310/15:43900680 - isvavai.cz</a>
Result on the web
<a href="http://www.icct.cz/2015/Full_Papers_ICCT_2015.pdf" target="_blank" >http://www.icct.cz/2015/Full_Papers_ICCT_2015.pdf</a>
DOI - Digital Object Identifier
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Alternative languages
Result language
angličtina
Original language name
Optimizing Flow And Segregation Properties Of Lactose/Microcrystalline Cellulose Mixture For Tablet Compression
Original language description
The present study deals with optimizing the flow and segregation properties of levocetirizine hydrochloride formulation, where the delay between homogenization and tablet compression was found to affect the tablet content uniformity. In addition to API,the base formulation comprised spray dried lactose monohydrate, milled lactose monohydrate 200 mesh, Avicel PH 101 microcrystalline cellulose, and minor excipients. Several alternative mixtures were prepared using the same total composition, but different grades of lactose and microcrystalline cellulose. These mixtures were then tested for the segregation behavior in an in-house segregation device and the flow properties using the Freeman FT4 powder rheometer. The segregation tests showed the grade of lactose is essential for mixture in-flow segregation. While SD lactose mixtures increased the API content in a direction countercurrent to flow, the milled lactose mixtures segregated API concurrently. Mixtures using both lactose grades sh
Czech name
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Czech description
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Classification
Type
D - Article in proceedings
CEP classification
JJ - Other materials
OECD FORD branch
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Result continuities
Project
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Continuities
S - Specificky vyzkum na vysokych skolach
Others
Publication year
2015
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Article name in the collection
Proceedings of the 3rd International Conference on Chemical Technology
ISBN
978-80-86238-79-1
ISSN
2336-811X
e-ISSN
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Number of pages
6
Pages from-to
478-483
Publisher name
Česká společnost průmyslové chemie (ČSPCH)
Place of publication
Praha
Event location
Mikulov
Event date
Apr 13, 2015
Type of event by nationality
WRD - Celosvětová akce
UT code for WoS article
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