Influence of surface pre-treatment on the cytocompatibility of a novel biodegradable ZnMg alloy
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60461373%3A22310%2F16%3A43901848" target="_blank" >RIV/60461373:22310/16:43901848 - isvavai.cz</a>
Result on the web
<a href="http://www.sciencedirect.com/science/article/pii/S092849311630546X" target="_blank" >http://www.sciencedirect.com/science/article/pii/S092849311630546X</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.msec.2016.05.114" target="_blank" >10.1016/j.msec.2016.05.114</a>
Alternative languages
Result language
angličtina
Original language name
Influence of surface pre-treatment on the cytocompatibility of a novel biodegradable ZnMg alloy
Original language description
Degradable zinc-based alloys with an appropriate corrosion rate are promising materials for the preparation of temporary orthopaedic implants. Previously, we prepared and characterised a novel Zn1.5Mg alloy. This paper is focused on the characterisation of this alloy after a surface pre-treatment, which should mimic processes occurring in vivo. The samples of the Zn1.5Mg alloy were immersed in a simulated body fluid (SBF) at 37 degrees C for 14 days in order to form a protective layer of corrosion products. Thereafter, these samples were used for the corrosion rate determination, an indirect in vitro cytotoxicity test, as well as for a direct contact test and were compared with the non-treated samples. The protective layer was characterized by SEM and its chemical composition was determined by EDS and XPS analysis. The corrosion rate was significantly decreased after the pre-incubation. The protective layer of corrosion products was rich in Ca and P. The pre-incubated samples exhibited increased cytocompatibility in the indirect test (metabolic activity of L929 cells was above 70%) and we also observed osteoblast-like cell growth directly on the samples during the contact tests. Thus, the pre-incubation in SBF leading to improved cytocompatibility could represent more appropriate model to in vivo testing.
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
JK - Corrosion and material surfaces
OECD FORD branch
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Result continuities
Project
<a href="/en/project/GBP108%2F12%2FG043" target="_blank" >GBP108/12/G043: Interface controlled properties of micro/nanocrystalline materials for advanced structural applications, biodegradable implants and hydrogen storage</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2016
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Materials science and engineering C
ISSN
0928-4931
e-ISSN
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Volume of the periodical
68
Issue of the periodical within the volume
listopad 2016
Country of publishing house
NL - THE KINGDOM OF THE NETHERLANDS
Number of pages
7
Pages from-to
198-204
UT code for WoS article
000382600000025
EID of the result in the Scopus database
2-s2.0-84973369809