Meta Substitution of Calixarenes

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60461373%3A22310%2F16%3A43902668" target="_blank" >RIV/60461373:22310/16:43902668 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.1007/978-3-319-31867-7" target="_blank" >http://dx.doi.org/10.1007/978-3-319-31867-7</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1007/978-3-319-31867-7" target="_blank" >10.1007/978-3-319-31867-7</a>

Result language
angličtina
Original language name
Meta Substitution of Calixarenes
Original language description
The electrophilic aromatic substitutions of calixarenes usually lead to their para-substituted derivatives due to the directing effect of hydroxy or alkoxy groups. However, introducing even one substituent to a meta-position, we can obtain inherently chiral compounds which, for example, could be used as ligands in enantioselective reactions. Whereas procedures leading to para-substituted derivatives are already quite well-known in calixarene chemistry, meta-substitutions usually need more demanding approaches to force the calixarene system to react in its meta-positions. In this chapter, we highlight the most common ways to obtain these derivatives: step-by-step fragment condensations, the use of ortho-orienting groups or intramolecular ring closing of already para-substituted compounds, p-bromodienone route and direct mercuration reactions leading to useful intermediates for further transformations.
Czech name
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Czech description
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Project
<a href="/en/project/GAP207%2F12%2F2027" target="_blank" >GAP207/12/2027: Synthesis and applications of inherently chiral calixarenes</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year
2016
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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