Enhanced solubility of nanostructured paracetamol

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60461373%3A22310%2F17%3A43901727" target="_blank" >RIV/60461373:22310/17:43901727 - isvavai.cz</a>

Result on the web

<a href="http://iopscience.iop.org/article/10.1088/2057-1976/2/5/055007/pdf" target="_blank" >http://iopscience.iop.org/article/10.1088/2057-1976/2/5/055007/pdf</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1088/2057-1976/2/5/055007" target="_blank" >10.1088/2057-1976/2/5/055007</a>

Result language

angličtina

Original language name

Enhanced solubility of nanostructured paracetamol

Original language description

Athermodynamic top-down approach was used for quantitative prediction of the influence of size and shape of monoclinic paracetamol nanoparticles on their solubility in pure water. A thorough analysis of published experimental data on the bulk paracetamol solubility in water and its melting properties was performed and a temperature dependence of the limiting activity coefficient of paracetamol in the saturated aqueous solution was assessed. Next, the equilibrium condition for the nanostructured paracetamol solubility is derived considering various nanoparticles shapes and the size-dependent interfacial energy at the solid paracetamol/liquid solution interface. Calculation of solubility was performed for spherical particles of radius 1?50 nmas well as for elongated cylindrical particles of various aspect ratios. Size-dependence of interfacial energy gives a maximal solubility for spherical nanoparticles of some critical radius rc. Predicted solubility of cylindrical nanoparticles is greater than for spherical nanoparticles of the same volume due to higher surface-to-volume ratio and higher average interfacial energy corresponding to shape-dependent changes of particle morphology.

Czech name

—

Czech description

—

Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

10402 - Inorganic and nuclear chemistry

Project

—

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2017

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Biomedical Physics and Engineering Express

ISSN

2057-1976

e-ISSN

—

Volume of the periodical

2

Issue of the periodical within the volume

5

Country of publishing house

GB - UNITED KINGDOM

Number of pages

9

Pages from-to

055007

UT code for WoS article

000407441500007

EID of the result in the Scopus database

—