Identification of the Minimal Glycotope of Streptococcus pneumoniae 7F Capsular Polysaccharide using Synthetic Oligosaccharides
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60461373%3A22310%2F18%3A43918961" target="_blank" >RIV/60461373:22310/18:43918961 - isvavai.cz</a>
Alternative codes found
RIV/60461373:22810/18:43918961
Result on the web
<a href="https://onlinelibrary.wiley.com/doi/full/10.1002/chem.201705379" target="_blank" >https://onlinelibrary.wiley.com/doi/full/10.1002/chem.201705379</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1002/chem.201705379" target="_blank" >10.1002/chem.201705379</a>
Alternative languages
Result language
angličtina
Original language name
Identification of the Minimal Glycotope of Streptococcus pneumoniae 7F Capsular Polysaccharide using Synthetic Oligosaccharides
Original language description
Streptococcus pneumoniae causes life-threatening diseases including meningitis, pneumonia and sepsis. Existing glycoconjugate vaccines based on purified capsular polysaccharides are widely used and help to prevent millions of deaths every year. Herein, the total syntheses of oligosaccharides resembling portions of the S. pneumoniae serotype 7F (ST7F) capsular polysaccharide repeating unit are report-ed. To define minimal glycan epitopes, glycan microarrays containing the synthetic oligosaccharides were used to screen human reference serum and revealed that both side chains of the ST7F play a key role in antigen recognition. The identification of protective minimal epitopes is vital to design efficient semi-and fully-synthetic glycoconjugate vaccines.
Czech name
—
Czech description
—
Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
—
OECD FORD branch
10401 - Organic chemistry
Result continuities
Project
—
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2018
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Chemistry A European Journal
ISSN
0947-6539
e-ISSN
—
Volume of the periodical
24
Issue of the periodical within the volume
16
Country of publishing house
DE - GERMANY
Number of pages
7
Pages from-to
4181-4187
UT code for WoS article
000427563000036
EID of the result in the Scopus database
2-s2.0-85042224925