Benzene IARC Monographs on the Evaluation of Carcinogenic Risks to Humans Volume 120

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60461373%3A22310%2F18%3A43921041" target="_blank" >RIV/60461373:22310/18:43921041 - isvavai.cz</a>
Result on the web
<a href="https://publications.iarc.fr/Book-And-Report-Series/Iarc-Monographs-On-The-Identification-Of-Carcinogenic-Hazards-To-Humans/Benzene-2018" target="_blank" >https://publications.iarc.fr/Book-And-Report-Series/Iarc-Monographs-On-The-Identification-Of-Carcinogenic-Hazards-To-Humans/Benzene-2018</a>
DOI - Digital Object Identifier
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Result language
angličtina
Original language name
Benzene IARC Monographs on the Evaluation of Carcinogenic Risks to Humans Volume 120
Original language description
Benzene is carcinogenic to human (Group 1 carcinogen). There is sufficient evidence in humans for the carcinogenicity of benzene. Benzene causes acute myeloid leukaemia in adults. Positive associations have been observed for non-Hodgkin lymphoma, chronic lymphoid leukaemia, multiple myeloma, chronic myeloid leukaemia, acute myeloid leukaemia in children, and cancer of the lung. There is sufficient evidence in experimental animals for the carcinogenicity of benzene. A Group 1 evaluation was supported by mechanistic data demonstrating that benzene exhibits many of the key characteristics of carcinogens. In particular, there is strong evidence, including in exposed humans, that benzene: is metabolically activated to electrophilic metabolites; induces oxidative stress and associated oxidative DNA damage; is genotoxic, inducing DNA damage and chromosomal changes; is immunosuppressive; and causes haematotoxicity.
Czech name
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Czech description
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Project
<a href="/en/project/2B08051" target="_blank" >2B08051: New Strategy for Biological Monitoring of Exposure to Mutagens and Carcinogens</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year
2018
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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