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Bacterial intoxication evokes cellular senescence with persistent DNA damage and cytokine signalling

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378050%3A_____%2F09%3A00347149" target="_blank" >RIV/68378050:_____/09:00347149 - isvavai.cz</a>

  • Result on the web

  • DOI - Digital Object Identifier

Alternative languages

  • Result language

    angličtina

  • Original language name

    Bacterial intoxication evokes cellular senescence with persistent DNA damage and cytokine signalling

  • Original language description

    Cytolethal distending toxins (CDT) are proteins produced and secreted by facultative pathogenic strains of gram-negative bacteria with potentially genotoxic effects. We found both normal and cancer human cells exposed to CDT, surviving the acute phase ofintoxication by Haemophilus ducreyi CDT, possess the main hallmarks of cellular senescence including persistently activated DNA damage signalling, expansion of promyelocytic leukaemia nuclear compartment and induced expression of several cytokines (e.g.IL-6, IL-8 and IL-24). We conclude that analogous to oncogenic, oxidative and replicative stresses, bacterial toxins represent another pathophysiological stimulus that induces premature senescence. Thus, the activation of cellular senescence as the anticancer barrier, together with evidence of chromosomal defects reported here, support the emerging genotoxic and potentially oncogenic effects of this group of bacterial toxins, and warrant further research of their role in human disease.

  • Czech name

  • Czech description

Classification

  • Type

    J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

  • CEP classification

    EB - Genetics and molecular biology

  • OECD FORD branch

Result continuities

  • Project

    Result was created during the realization of more than one project. More information in the Projects tab.

  • Continuities

    P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>Z - Vyzkumny zamer (s odkazem do CEZ)

Others

  • Publication year

    2009

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    Journal of Cellular and Molecular Medicine

  • ISSN

    1582-1838

  • e-ISSN

  • Volume of the periodical

    14

  • Issue of the periodical within the volume

    1-2

  • Country of publishing house

    GB - UNITED KINGDOM

  • Number of pages

    11

  • Pages from-to

  • UT code for WoS article

    000275639700031

  • EID of the result in the Scopus database