Self-Propelled Autonomous Mg/Pt Janus Micromotor Interaction with Human Cells
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60461373%3A22310%2F19%3A43918300" target="_blank" >RIV/60461373:22310/19:43918300 - isvavai.cz</a>
Alternative codes found
RIV/00216305:26620/19:PU136230
Result on the web
<a href="https://www.journal.csj.jp/doi/10.1246/bcsj.20190104" target="_blank" >https://www.journal.csj.jp/doi/10.1246/bcsj.20190104</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1246/bcsj.20190104" target="_blank" >10.1246/bcsj.20190104</a>
Alternative languages
Result language
angličtina
Original language name
Self-Propelled Autonomous Mg/Pt Janus Micromotor Interaction with Human Cells
Original language description
Magnesium (Mg)-based micromotors have attracted considerable attention as they are capable of moving in water and human blood plasma without external fuels. It has also been demonstrated that they have potential for drug delivery in mouse stomach. However, their biocompatibility and cytotoxicity to human cells have yet to be studied. Therefore, we performed cytotoxicity study of Mg/Pt Janus micromotors with human lung carcinoma epithelial cells (A549), human breast cancer cells (MCF-7), human embryonic kidney cells (HEK-293), human liver carcinoma cells (HepG2) and human cervical cancer cells (HeLa). The highest concentration of micromotors tested, 200 mu g mL(-1), drastically induced a high toxic effect on the cells and reduced the cell viability to below 60%. This shows while Pt/Au nanomachines were found to be safe previously, this is not the case of the Mg/Pt micromachines.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10402 - Inorganic and nuclear chemistry
Result continuities
Project
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Continuities
O - Projekt operacniho programu
Others
Publication year
2019
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Bulletin of the Chemical Society of Japan
ISSN
0009-2673
e-ISSN
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Volume of the periodical
92
Issue of the periodical within the volume
10
Country of publishing house
JP - JAPAN
Number of pages
5
Pages from-to
1754-1758
UT code for WoS article
000485218200013
EID of the result in the Scopus database
2-s2.0-85072645454