Mechanistic role of plant-based bitter principles and bitterness prediction for natural product studies I: Database and methods
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60461373%3A22310%2F19%3A43919270" target="_blank" >RIV/60461373:22310/19:43919270 - isvavai.cz</a>
Result on the web
<a href="https://www.degruyter.com/view/j/psr.2019.4.issue-7/psr-2018-0117/psr-2018-0117.xml" target="_blank" >https://www.degruyter.com/view/j/psr.2019.4.issue-7/psr-2018-0117/psr-2018-0117.xml</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1515/psr-2018-0117" target="_blank" >10.1515/psr-2018-0117</a>
Alternative languages
Result language
angličtina
Original language name
Mechanistic role of plant-based bitter principles and bitterness prediction for natural product studies I: Database and methods
Original language description
This chapter discusses the rationale behind the bitter sensation elicited by chemical compounds, focusing on natural products. Emphasis has been placed on a brief presentation of BitterDB (the database of bitter compounds), along with available methods for the prediction of bitterness in compounds. The fundamental basis for explaining bitterness has been provided, based on the structural features of human bitter taste receptors and have been used to shed light on the mechanistic role of a few out of the 25 known human taste receptors to provide the foundation for understanding how bitter compounds interact with their receptors. Some case studies of ligand-based prediction models based on 2D fingerprints and 3D pharmacophores, along with machine learning methods have been provided. The chapter closes with an attempt to establish the relationship between bitterness and toxicity.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10611 - Plant sciences, botany
Result continuities
Project
<a href="/en/project/EF16_027%2F0008351" target="_blank" >EF16_027/0008351: ChemJets UCT Prague</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2019
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Physical Sciences Reviews
ISSN
2365-6581
e-ISSN
2365-659X
Volume of the periodical
4
Issue of the periodical within the volume
7
Country of publishing house
DE - GERMANY
Number of pages
11
Pages from-to
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UT code for WoS article
000472606200003
EID of the result in the Scopus database
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