IMPACT OF COMPRESSION PRESSURE ON PHARMACEUTICAL FORMULATIONS CONTAINING MAGNESIUM ALUMINOMETASILICATES

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60461373%3A22310%2F19%3A43920063" target="_blank" >RIV/60461373:22310/19:43920063 - isvavai.cz</a>

Result on the web

<a href="https://www.researchgate.net/profile/Pavlina_Kominova/publications" target="_blank" >https://www.researchgate.net/profile/Pavlina_Kominova/publications</a>

DOI - Digital Object Identifier

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Result language

angličtina

Original language name

IMPACT OF COMPRESSION PRESSURE ON PHARMACEUTICAL FORMULATIONS CONTAINING MAGNESIUM ALUMINOMETASILICATES

Original language description

In pharmaceutical industry, free flow behaviour of powders is a precondition for an unproblematic production process and final product quality for e.g. capsules and tablets. Flow properties of powders can be improved significantly by the addition of small amount of glidants that diminish attractive forces among particles. Based on our previous research focused on the character of novel glidant family - magnesium aluminometasilicates (MAS), repulsive character of their particles was observed in case of very low pressure conditions (free flow powder) and corresponded to their glidant effect. However, the predisposition to form particle interactions between the MAS particles and between MAS and the other excipient particle appeared at applied high pressures (tablet formed). Therefore, the intention of this study was to characterize behaviour of powder mixtures containing MAS during their exposure to different pressures. Results revealed MAS particles retained their repulsive character and small contact surface area under normal conditions. If threshold pressure is applied, the destruction of MAS particles and formation of new surfaces leading to particle interactions are observed. Ability of MAS particles to form interactions intensifies with increasing pressure. This &quot;function switching&quot; makes the MAS materials suitable for using as multifunctional excipients in direct tablet compression when they act as a glidant or a binder depending on applied pressure.

Czech name

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Czech description

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Type

A - Audiovisual production

CEP classification

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OECD FORD branch

30104 - Pharmacology and pharmacy

Project

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Continuities

S - Specificky vyzkum na vysokych skolach

Publication year

2019

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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