Stress-Dependent Particle Interactions of Magnesium Aluminometasilicates as Their Performance Factor in Powder Flow and Compaction Applications
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F67985858%3A_____%2F21%3A00559332" target="_blank" >RIV/67985858:_____/21:00559332 - isvavai.cz</a>
Result on the web
<a href="https://mdpi-res.com/d_attachment/materials/materials-14-00900/article_deploy/materials-14-00900-v3.pdf?version=1614074212" target="_blank" >https://mdpi-res.com/d_attachment/materials/materials-14-00900/article_deploy/materials-14-00900-v3.pdf?version=1614074212</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.3390/ma14040900" target="_blank" >10.3390/ma14040900</a>
Alternative languages
Result language
angličtina
Original language name
Stress-Dependent Particle Interactions of Magnesium Aluminometasilicates as Their Performance Factor in Powder Flow and Compaction Applications
Original language description
In the pharmaceutical industry, silicates are commonly used excipients with different application possibilities. They are especially utilized as glidants in low concentrations, but they can be used in high concentrations as porous carriers and coating materials in oral solid drug delivery systems. The desirable formulations of such systems must exhibit good powder flow but also good compactibility, which brings opposing requirements on inter-particle interactions. Since magnesium aluminometasilicates (MAS) are known for their interesting flow behavior reported as negative cohesivity yet they can be used as binders for tablet compression, the objective of this experimental study was to investigate their particle interactions within a broad range of mechanical stress from several kPa to hundreds of MPa. Magnesium aluminometasilicate (Neusilin(R) US2 and Neusilin(R) S2)-microcrystalline cellulose (Avicel(R) PH102) physical powder mixtures with varying silicate concentrations were prepared and examined during their exposure to different pressures using powder rheology and compaction analysis. The results revealed that MAS particles retain their repulsive character and small contact surface area under normal conditions. If threshold pressure is applied, the destruction of MAS particles and formation of new surfaces leading to particle interactions are observed. The ability of MAS particles to form interactions intensifies with increasing pressure and their amount in a mixture. This function switching makes MAS suitable for use as multifunctional excipients since they can act as a glidant or a binder depending on the applied pressure.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
20402 - Chemical process engineering
Result continuities
Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2021
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Minerals
ISSN
2075-163X
e-ISSN
2075-163X
Volume of the periodical
14
Issue of the periodical within the volume
4
Country of publishing house
CH - SWITZERLAND
Number of pages
15
Pages from-to
900
UT code for WoS article
000624116400001
EID of the result in the Scopus database
2-s2.0-85101277276