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Plla honeycomb‐like pattern on fluorinated ethylene propylene as a substrate for fibroblast growth

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60461373%3A22310%2F20%3A43920912" target="_blank" >RIV/60461373:22310/20:43920912 - isvavai.cz</a>

  • Alternative codes found

    RIV/60461373:22330/20:43920912

  • Result on the web

    <a href="https://doi.org/10.3390/polym12112436" target="_blank" >https://doi.org/10.3390/polym12112436</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.3390/polym12112436" target="_blank" >10.3390/polym12112436</a>

Alternative languages

  • Result language

    angličtina

  • Original language name

    Plla honeycomb‐like pattern on fluorinated ethylene propylene as a substrate for fibroblast growth

  • Original language description

    In this study, we present the surface patterning of a biopolymer poly(L‐lactide) (PLLA) for fibroblast growth enhancement. The patterning is based on a self‐organized pore arrangement directly fabricated from a ternary system of a solvent‐nonsolvent biopolymer. We successfully created a porous honeycomb‐like pattern (HCP) on a thermally resistant polymer—fluorinated ethylene propylene (FEP). An important preparation step for HCP is activation of the substrate in Ar plasma discharge. The polymer activation leads to changes in the surface chemistry, which corresponds to an increase in the substrate surface wettability. The aim of this study was to evaluate the influence of the PLLA concentration in solution on the surface morphology, roughness, wettability, and chemistry, and subsequently, also on fibroblast proliferation. We confirmed that the amount of PLLA in solution significantly affects the material surface properties. The pore size of the prepared layers, the surface wettability, and the surface oxygen content increased with an increasing amount of biopolymer in the coating solution. The optimal amount was 1 g of PLLA, which resulted in the highest number of cells after 6 days from seeding; however, all three biopolymer concentrations exhibited significantly better results compared to pristine FEP. The cytocompatibility tests showed that the HCP promoted the attachment of cell filopodia to the underlying substrate and, thus, significantly improved the cell–material interactions. We prepared a honeycomb biodegradable support for enhanced cell growth, so the surface properties of perfluoroethylenepropylene were significantly enhanced.

  • Czech name

  • Czech description

Classification

  • Type

    J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database

  • CEP classification

  • OECD FORD branch

    20501 - Materials engineering

Result continuities

  • Project

    <a href="/en/project/GA19-02495S" target="_blank" >GA19-02495S: Honeycomb like functionalized microporous polymers</a><br>

  • Continuities

    P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Others

  • Publication year

    2020

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    Polymers

  • ISSN

    2073-4360

  • e-ISSN

  • Volume of the periodical

    12

  • Issue of the periodical within the volume

    11

  • Country of publishing house

    CH - SWITZERLAND

  • Number of pages

    12

  • Pages from-to

    "2436/1"-12

  • UT code for WoS article

    000593883000001

  • EID of the result in the Scopus database

    2-s2.0-85093972244