Cytocompatibility of polymethyl methacrylate honeycomb-like pattern on perfluorinated polymer

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60461373%3A22310%2F21%3A43923038" target="_blank" >RIV/60461373:22310/21:43923038 - isvavai.cz</a>

Alternative codes found

RIV/60461373:22330/21:43923038

Result on the web

<a href="https://doi.org/10.3390/polym13213663" target="_blank" >https://doi.org/10.3390/polym13213663</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.3390/polym13213663" target="_blank" >10.3390/polym13213663</a>

Result language

angličtina

Original language name

Cytocompatibility of polymethyl methacrylate honeycomb-like pattern on perfluorinated polymer

Original language description

In this study, we present a simple approach for developing a biocompatible polymer scaffold with a honeycomb-like micropattern. We aimed to combine a plasma treatment of fluorinated ethylene propylene (FEP) substrate with an improved phase separation technique. The plasma exposure served for modification of the polymer surface properties, such as roughness, surface chemistry, and wettability. The treated FEP substrate was applied for the growth of a honeycomb-like pattern from a solution of polymethyl methacrylate (PMMA). The properties of the pattern were strongly dependent on the conditions of plasma exposure of the FEP substrate. The physico-chemical properties of the prepared pattern, such as changes in wettability, aging, morphology, and surface chemistry, were determined. Further, we have examined the cellular response of human osteoblasts (U-2 OS) on the modified substrates. The micropattern prepared with a selected combination of surface activation and amount of PMMA for honeycomb construction showed a positive effect on U-2 OS cell adhesion and proliferation. Samples with higher PMMA content (3 and 4 g) formed more periodic hexagonal structures on the surface compared to its lower amount (1 and 2 g), which led to a significant increase in the pattern cytocompatibility compared to pristine or plasma-treated FEP.

Czech name

—

Czech description

—

Type

J_SC - Article in a specialist periodical, which is included in the SCOPUS database

CEP classification

—

OECD FORD branch

20501 - Materials engineering

Project

<a href="/en/project/GA19-02495S" target="_blank" >GA19-02495S: Honeycomb like functionalized microporous polymers</a><br>

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2021

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Polymers

ISSN

2073-4360

e-ISSN

—

Volume of the periodical

13

Issue of the periodical within the volume

21

Country of publishing house

CH - SWITZERLAND

Number of pages

15

Pages from-to

"3663/1"-15

UT code for WoS article

—

EID of the result in the Scopus database

2-s2.0-85117923590