In vitro evaluation of a novel nanostructured Ti-36Nb-6Ta alloy for orthopedic applications
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60461373%3A22310%2F20%3A43921596" target="_blank" >RIV/60461373:22310/20:43921596 - isvavai.cz</a>
Alternative codes found
RIV/68378041:_____/20:00539761 RIV/68407700:21220/20:00342121 RIV/68407700:21460/20:00342121 RIV/00216208:11130/20:10413223 RIV/00216208:11310/20:10413223
Result on the web
<a href="https://www.futuremedicine.com/doi/10.2217/nnm-2020-0123" target="_blank" >https://www.futuremedicine.com/doi/10.2217/nnm-2020-0123</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.2217/nnm-2020-0123" target="_blank" >10.2217/nnm-2020-0123</a>
Alternative languages
Result language
angličtina
Original language name
In vitro evaluation of a novel nanostructured Ti-36Nb-6Ta alloy for orthopedic applications
Original language description
Aim:To evaluate the impact of a nanostructured surface created on beta-titanium alloy, Ti-36Nb-6Ta, on the growth and differentiation of human mesenchymal stem cells.Materials & methods:The nanotubes, with average diameters 18, 36 and 46 nm, were prepared by anodic oxidation. Morphology, hydrophilicity and mechanical properties of the nanotube layers were characterized. The biocompatibility and osteogenic potential of the nanostructured surfaces were established using variousin vitroassays, scanning electron microscopy and confocal microscopy.Results:The nanotubes lowered elastic modulus close to that of bone, positively influenced cell adhesion, improved ALP activity, synthesis of type I collagen and osteocalcin expression, but diminished early cell proliferation.Conclusion:Nanostructured Ti-36Nb-6Ta with nanotube diameters 36 nm was the most promising material for bone implantation.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
20501 - Materials engineering
Result continuities
Project
<a href="/en/project/GA16-14758S" target="_blank" >GA16-14758S: Influence of surface nanotopography on bioactive properties of low modulus titanium alloy.</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2020
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Nanomedicine
ISSN
1743-5889
e-ISSN
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Volume of the periodical
15
Issue of the periodical within the volume
19
Country of publishing house
GB - UNITED KINGDOM
Number of pages
17
Pages from-to
1843-1859
UT code for WoS article
000555449300001
EID of the result in the Scopus database
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