Modelling the role of membrane mechanics in cell adhesion on titanium oxide nanotubes
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378041%3A_____%2F23%3A00583165" target="_blank" >RIV/68378041:_____/23:00583165 - isvavai.cz</a>
Alternative codes found
RIV/60461373:22310/22:43925155 RIV/00064203:_____/23:10442868
Result on the web
<a href="https://www.tandfonline.com/doi/full/10.1080/10255842.2022.2058875" target="_blank" >https://www.tandfonline.com/doi/full/10.1080/10255842.2022.2058875</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1080/10255842.2022.2058875" target="_blank" >10.1080/10255842.2022.2058875</a>
Alternative languages
Result language
angličtina
Original language name
Modelling the role of membrane mechanics in cell adhesion on titanium oxide nanotubes
Original language description
nTitanium surface treated with titanium oxide nanotubes was used in many studies to quantify the effect of surface topography on cell fate. However, the predicted optimal diameter of nanotubes considerably differs among studies. We propose a model that explains cell adhesion to a nanostructured surface by considering the deformation energy of cell protrusions into titanium nanotubes and the adhesion to the surface. The optimal surface topology is defined as a geometry that gives the membrane a minimum energy shape. A dimensionless parameter, the cell interaction index, was proposed to describe the interplay between the cell membrane bending, the intrinsic curvature, and the strength of cell adhesion. Model simulation shows that an optimal nanotube diameter ranging from 20 nm to 100 nm (cell interaction index between 0.2 and 1, respectively) is feasible within a certain range of parameters describing cell membrane adhesion and bending. The results indicate a possibility to tune the topology of a nanostructural surface in order to enhance the proliferation and differentiation of cells mechanically compatible with the given surface geometry while suppressing the growth of other mechanically incompatible cells.
Czech name
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Czech description
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Classification
Type
J<sub>SC</sub> - Article in a specialist periodical, which is included in the SCOPUS database
CEP classification
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OECD FORD branch
10610 - Biophysics
Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2023
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Computer methods in biomechanics and biomedical engineering
ISSN
1025-5842
e-ISSN
1476-8259
Volume of the periodical
26
Issue of the periodical within the volume
3
Country of publishing house
US - UNITED STATES
Number of pages
10
Pages from-to
281-290
UT code for WoS article
000778467000001
EID of the result in the Scopus database
2-s2.0-85128231530