Trans-palladium complexes with 1-adamantanamine and various halide ions: Synthesis, characterization, DNA and protein binding and in vitro cytotoxicity

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60461373%3A22310%2F21%3A43922363" target="_blank" >RIV/60461373:22310/21:43922363 - isvavai.cz</a>

Alternative codes found

RIV/60461373:22330/21:43922363 RIV/60461373:22340/21:43922363

Result on the web

<a href="https://www.sciencedirect.com/science/article/pii/S027753872100440X" target="_blank" >https://www.sciencedirect.com/science/article/pii/S027753872100440X</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.poly.2021.115458" target="_blank" >10.1016/j.poly.2021.115458</a>

Result language

angličtina

Original language name

Trans-palladium complexes with 1-adamantanamine and various halide ions: Synthesis, characterization, DNA and protein binding and in vitro cytotoxicity

Original language description

Research into the antitumor effects of transition metals has been devoted to the decades since the discovery of the cytostatic properties of the platinum complex cisplatin, which despite numerous side effects, is still one of the most prescribed cytostatics. A promising way to develop a new similar complex is to select a suitable ligand. An interesting group of ligands is diamantanoid derivatives, which, due to their high lipophilicity and bulk, show promising pharmacological properties. With this in mind, we have prepared three trans-palladium(II) complexes with bulky 1-adamantanamine and different halide ligands (chlorine, bromine and iodine). The complexes (1-3) were analytically characterized to confirm their structures by FT-IR, 1H and 13C NMR, HR-MS and XRD techniques for the first time. The interaction of DNA with complexes 1-3 was investigated and the affinity to DNA was confirmed by a DNA binding study, gel electrophoresis and electronic circular dichroism. A protein binding study was carried out and a weak interaction with proteins was found. Finally, the anticancer abilities of palladium complexes 1-3, compared to another cytostatic drug oxaliplatin, were tested and confirmed on the cancer cell lines RAW, HeLa, HOC and HL-60, and the healthy cell line MRC-5.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

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OECD FORD branch

30502 - Other medical science

Project

<a href="/en/project/GA21-11688S" target="_blank" >GA21-11688S: Core-shell nanoparticles for targeted X-ray-induced photodynamic therapy</a><br>

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2021

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Polyhedron

ISSN

0277-5387

e-ISSN

—

Volume of the periodical

209

Issue of the periodical within the volume

November

Country of publishing house

GB - UNITED KINGDOM

Number of pages

9

Pages from-to

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UT code for WoS article

000697059300005

EID of the result in the Scopus database

2-s2.0-85115603345