HIGHLY SENSITIVE MICROFLUIDIC SENSOR ARCHITECTURE FOR SERS MEASUREMENTS OF HORMONES
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60461373%3A22310%2F21%3A43923371" target="_blank" >RIV/60461373:22310/21:43923371 - isvavai.cz</a>
Result on the web
<a href="https://doi.org/10.37904/nanocon.2020.3743" target="_blank" >https://doi.org/10.37904/nanocon.2020.3743</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.37904/nanocon.2020.3743" target="_blank" >10.37904/nanocon.2020.3743</a>
Alternative languages
Result language
angličtina
Original language name
HIGHLY SENSITIVE MICROFLUIDIC SENSOR ARCHITECTURE FOR SERS MEASUREMENTS OF HORMONES
Original language description
Today, there is considerable interest in the development of microfluidic chips that can be integrated into various analytical devices and further used for chemical or biological research. The microfluidic approach can reduce the size of all types of analytical laboratory equipment's and improve their technological performances. In addition, in combination with Surface Enhanced Raman Scattering (SERS), microfluidic devices can detect unprecedentedly low concentrations of targeted analytes. SERS provides a significant amplification of the nonlinear optical response of a molecule adsorbed on a suitable plasmon-active (most often silver or gold) surface (for example nanograting, nanoparticles, etc.). On the other hand, microfluidics allows a substantial reduction in the volume of sample required for analysis. In this work, an approach based on a combination of SERS and microfluidics was implemented and enables the detection of low concentrations of the target analyte - hormones. Proposed preparation of microfluidic chip comprises several subsequent steps: (i) preparation of microfluidic platform using 3D printing; (ii) laser assisted creation of patterned surface, further covered by a thin Au layer, ensuring the excitation of surface plasmon polariton in the microfluidic canal, (iii) subsequent grafting of -NH2 groups, and their activation for hormones entrapping. The rapid, reproducible, and ultrasensitive detection of hormones - Bisphenol, Estradiol, Estriol 10(-6) M) was achieved.
Czech name
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Czech description
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Classification
Type
D - Article in proceedings
CEP classification
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OECD FORD branch
20501 - Materials engineering
Result continuities
Project
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Continuities
S - Specificky vyzkum na vysokych skolach
Others
Publication year
2021
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Article name in the collection
12TH INTERNATIONAL CONFERENCE ON NANOMATERIALS - RESEARCH &amp; APPLICATION (NANOCON 2020)
ISBN
978-80-87294-98-7
ISSN
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e-ISSN
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Number of pages
5
Pages from-to
399-403
Publisher name
Tanger s.r.o.
Place of publication
Ostrava
Event location
Brno
Event date
Oct 21, 2020
Type of event by nationality
WRD - Celosvětová akce
UT code for WoS article
000664505500068