The effect of chemical structure of OEG ligand shells with quaternary ammonium moiety on the colloidal stabilization, cellular uptake and photothermal stability of gold nanorods
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60461373%3A22310%2F21%3A43933915" target="_blank" >RIV/60461373:22310/21:43933915 - isvavai.cz</a>
Alternative codes found
RIV/68378050:_____/21:00544878 RIV/00179906:_____/21:10428287 RIV/68407700:21340/21:00350319 RIV/62690094:18470/21:50018089
Result on the web
<a href="https://www.dovepress.com/the-effect-of-chemical-structure-of-oeg-ligand-shells-with-quaternary--peer-reviewed-fulltext-article-IJN" target="_blank" >https://www.dovepress.com/the-effect-of-chemical-structure-of-oeg-ligand-shells-with-quaternary--peer-reviewed-fulltext-article-IJN</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.2147/IJN.S304953" target="_blank" >10.2147/IJN.S304953</a>
Alternative languages
Result language
angličtina
Original language name
The effect of chemical structure of OEG ligand shells with quaternary ammonium moiety on the colloidal stabilization, cellular uptake and photothermal stability of gold nanorods
Original language description
Purpose: Plasmonic photothermal cancer therapy by gold nanorods (GNRs) emerges as a promising tool for cancer treatment. The goal of this study was to design cationic oligoethylene glycol (OEG) compounds varying in hydrophobicity and molecular electrostatic potential as ligand shells of GNRs. Three series of ligands with different length of OEG chain (ethylene glycol units = 3, 4, 5) and variants of quaternary ammonium salts (QAS) as terminal functional group were synthesized and compared to a prototypical quaternary ammonium ligand with alkyl chain - (16-mercaptohexadecyl)trimethylammonium bromide (MTAB). Methods: Step-by-step research approach starting with the preparation of compounds characterized by NMR and HRMS spectra, GNRs ligand exchange evaluation through characterization of cytotoxicity and GNRs cellular uptake was used. A method quantifying the reshaping of GNRs was applied to determine the effect of ligand structure on the heat transport from GNRs under fs-laser irradiation. Results: Fourteen out of 18 synthesized OEG compounds successfully stabilized GNRs in the water. The colloidal stability of prepared GNRs in the cell culture medium decreased with the number of OEG units. In contrast, the cellular uptake of OEG+GNRs by HeLa cells increased with the length of OEG chain while the structure of the QAS group showed a minor role. Compared to MTAB, more hydrophilic OEG compounds exhibited nearly two order of magnitude lower cytotoxicity in free state and provided efficient cellular uptake of GNRs close to the level of MTAB. Regarding photothermal properties, OEG compounds evoked the photothermal reshaping of GNRs at lower peak fluence (14.8 mJ/cm2) of femtosecond laser irradiation than the alkanethiol MTAB. Conclusion: GNRs appear to be optimal for clinical applications with systemic administration of NPs not-requiring irradiation at high laser intensity such as drug delivery and photothermal therapy inducing apoptosis. © 2021 Salajkova et al.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
21000 - Nano-technology
Result continuities
Project
<a href="/en/project/EF15_003%2F0000444" target="_blank" >EF15_003/0000444: Advanced Functional Nanorobots</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2021
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
International Journal of Nanomedicine
ISSN
1178-2013
e-ISSN
1178-2013
Volume of the periodical
16
Issue of the periodical within the volume
MAY 2021
Country of publishing house
NZ - NEW ZEALAND
Number of pages
21
Pages from-to
3407-3427
UT code for WoS article
000651874100001
EID of the result in the Scopus database
2-s2.0-85106927892