Highly hydrophilic cationic gold nanorods stabilized by novel quaternary ammonium surfactant with negligible cytotoxicity
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68407700%3A21340%2F19%3A00340182" target="_blank" >RIV/68407700:21340/19:00340182 - isvavai.cz</a>
Alternative codes found
RIV/68378050:_____/19:00508786 RIV/00179906:_____/19:10395538 RIV/60162694:G44__/19:00555614 RIV/62690094:18470/19:50015740 RIV/00216208:11110/19:10395538
Result on the web
<a href="https://doi.org/10.1002/jbio.201900024" target="_blank" >https://doi.org/10.1002/jbio.201900024</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1002/jbio.201900024" target="_blank" >10.1002/jbio.201900024</a>
Alternative languages
Result language
angličtina
Original language name
Highly hydrophilic cationic gold nanorods stabilized by novel quaternary ammonium surfactant with negligible cytotoxicity
Original language description
The photothermal cancer therapy using cationic gold nanorods (GNRs) stabilized by quaternary ammonium salts (QAS) have a great potential to enhance conventional cancer treatment as it promises the effective eradication of cancer cells including cells resistant to radio- and chemo-therapy and the stimulation of anti tumor immune response. However, as the cytotoxicity of the conventional alkanethiol-QAS compounds limits their utility in medicine, here we developed GNRs modified by novel highly hydrophilic cationic surfactant composed of the quaternary ammonium group and ethylene glycol chain N,N,Ntrimethyl-3,6,9,12,15-pentaoxaheptadecyl-17-sulfanyl-1-ammonium bromide (POSAB) showing insignificant cytotoxicity in the free state. Surface modification of GNRs by POSAB allowed to prepare nanoparticles with good stability in water, high cellular uptake and localization in lysosomes that are a promising alternative to alkanethiolstabilized GNRs especially for biomedical applications.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
21002 - Nano-processes (applications on nano-scale); (biomaterials to be 2.9)
Result continuities
Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2019
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Journal of Biophotonics
ISSN
1864-063X
e-ISSN
1864-0648
Volume of the periodical
12
Issue of the periodical within the volume
12
Country of publishing house
US - UNITED STATES
Number of pages
6
Pages from-to
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UT code for WoS article
000479453700001
EID of the result in the Scopus database
2-s2.0-85069698323