Copper-Catalyzed Selective N-Arylation of Oxadiazolones by Diaryliodonium Salts

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60461373%3A22310%2F21%3A43934059" target="_blank" >RIV/60461373:22310/21:43934059 - isvavai.cz</a>

Result on the web

<a href="https://doi.org/10.1002/adsc.202100426" target="_blank" >https://doi.org/10.1002/adsc.202100426</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1002/adsc.202100426" target="_blank" >10.1002/adsc.202100426</a>

Result language

angličtina

Original language name

Copper-Catalyzed Selective N-Arylation of Oxadiazolones by Diaryliodonium Salts

Original language description

Here, we report the method for copper-catalyzed N-arylation of diverse oxadiazolones by diaryliodonium salts under mild conditions in high yields (up to 92%) using available CuI as a catalyst. The developed method allows utilizing both symmetric and unsymmetric diaryliodonium salts bearing auxiliary groups such as 2,4,6-trimethoxyphenyl (TMP). We found that the steric effects in aryl moieties determined the chemoselectivity of N- and O-arylation of the 1,2,4-oxadiazol-5(4H)-ones. Mesityl-substituted diaryliodonium salts demonstrated the high potential as a selective arylation reagent. The structural study suggests that steric accessibility of N-atom in 1,2,4-oxadiazol-5(4H)-ones impact to arylation with sterically hindered diaryliodonium salts. The synthetic application of proposed method was also demonstrated on selective arylation of 1,3,4-oxadiazol-2(3H)-ones and 1,2,4-oxadiazole-5-thiol. (Figure presented.). © 2021 Wiley-VCH GmbH

Czech name

—

Czech description

—

Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

10401 - Organic chemistry

Project

—

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2021

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

ADVANCED SYNTHESIS &amp; CATALYSIS

ISSN

1615-4150

e-ISSN

—

Volume of the periodical

363

Issue of the periodical within the volume

14

Country of publishing house

DE - GERMANY

Number of pages

11

Pages from-to

3566-3576

UT code for WoS article

000658836300001

EID of the result in the Scopus database

2-s2.0-85107761429