Fully Programmable Collective Behavior of Light-Powered Chemical Microrobotics: pH-Dependent Motion Behavior Switch and Controlled Cancer Cell Destruction
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60461373%3A22310%2F22%3A43924101" target="_blank" >RIV/60461373:22310/22:43924101 - isvavai.cz</a>
Alternative codes found
RIV/60461373:22330/22:43924101 RIV/60461373:22810/22:43924101 RIV/00216305:26620/22:PU145159
Result on the web
<a href="https://onlinelibrary.wiley.com/doi/full/10.1002/adfm.202205062" target="_blank" >https://onlinelibrary.wiley.com/doi/full/10.1002/adfm.202205062</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1002/adfm.202205062" target="_blank" >10.1002/adfm.202205062</a>
Alternative languages
Result language
angličtina
Original language name
Fully Programmable Collective Behavior of Light-Powered Chemical Microrobotics: pH-Dependent Motion Behavior Switch and Controlled Cancer Cell Destruction
Original language description
The development of fuel-free light-powered multi stimuli-responsive microrobots is becoming a vital field in biomedical research. The challenge is to design biomedical robots with precise motion control and novel functionalities such that one day they will stand alongside medical staff as fully fledged partners in the delivery of advanced non-invasive therapeutic procedures. In this study, a simple one-step etching/polymerization procedure is used to fabricate crystalline metal-organic framework structures surface-coated with a conductive polypyrrole (PPy) layer and then enriched with Methylene Blue sensitizer molecules. Due to the PPy surface charge, the microrobots start to move when exposed to a visible light source, enabling the controllable accumulation of the microrobots at the focal point of the light beam. Furthermore, a self-regulated motion is achieved by the PPy surface charge also providing a pH-dependent switch capable of altering microrobot behavior. In vitro study is conducted to test microrobot efficiency against human cervix carcinoma HeLa cells. It is shown that the micromotors are able to penetrate and successfully destroy the cancer cells. The work provides proof-of-concept for a novel strategy in which such microrobots can be guided by an optical beam, can self-regulate movement toward or away from each other, and can perform therapeutic functions with great efficiency.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10405 - Electrochemistry (dry cells, batteries, fuel cells, corrosion metals, electrolysis)
Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2022
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Advanced Functional Materials
ISSN
1616-301X
e-ISSN
1616-3028
Volume of the periodical
32
Issue of the periodical within the volume
38
Country of publishing house
US - UNITED STATES
Number of pages
15
Pages from-to
nestrankovano
UT code for WoS article
000824117000001
EID of the result in the Scopus database
2-s2.0-85133974330