Ultra-Small Gold Nanoparticles with Mild Immunomodulatory Activity as a Potential Tool for Bio-Applications
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60461373%3A22310%2F22%3A43925268" target="_blank" >RIV/60461373:22310/22:43925268 - isvavai.cz</a>
Alternative codes found
RIV/00064165:_____/22:10455007 RIV/00216208:11110/22:10455007 RIV/00216208:11140/22:10455007
Result on the web
<a href="https://fb.cuni.cz/file/6225/fb2022a0017.pdf" target="_blank" >https://fb.cuni.cz/file/6225/fb2022a0017.pdf</a>
DOI - Digital Object Identifier
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Alternative languages
Result language
angličtina
Original language name
Ultra-Small Gold Nanoparticles with Mild Immunomodulatory Activity as a Potential Tool for Bio-Applications
Original language description
Recently, more and more efforts are directed towards developing new imaging and drug-delivery options based on various nanoparticles, exploiting their unique properties. Here, ultra-small gold nanoparticles functionalized with widely used polyethylene glycol and its amine-terminated form were tested in respect of their potential interactions with human immune cells (cell line and primary cells). The results showed that differently terminated ultrasmall gold nanoparticles represent an interesting theranostic platform as they are harmless to immune cells (not inducing cytotoxicity and severe immune response) and on the other hand, they can serve as imaging and/or drug delivery agents using e.g. monocytes/ macrophages as “Trojan horses” to deliver these nanoparticles across the blood-brain barrier and diagnose or treat pathologies of the central nervous system.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
20501 - Materials engineering
Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
S - Specificky vyzkum na vysokych skolach<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2022
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Folia Biologica
ISSN
0015-5500
e-ISSN
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Volume of the periodical
68
Issue of the periodical within the volume
prosinec
Country of publishing house
CZ - CZECH REPUBLIC
Number of pages
11
Pages from-to
142-152
UT code for WoS article
000944551700003
EID of the result in the Scopus database
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