Smart multi stimuli-responsive electrospun nanofibers for on-demand drug release
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60461373%3A22310%2F23%3A43926159" target="_blank" >RIV/60461373:22310/23:43926159 - isvavai.cz</a>
Alternative codes found
RIV/60461373:22330/23:43926159
Result on the web
<a href="https://doi.org/10.1016/j.jcis.2023.05.181" target="_blank" >https://doi.org/10.1016/j.jcis.2023.05.181</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.jcis.2023.05.181" target="_blank" >10.1016/j.jcis.2023.05.181</a>
Alternative languages
Result language
angličtina
Original language name
Smart multi stimuli-responsive electrospun nanofibers for on-demand drug release
Original language description
Here, we report poly(N-isopropylacrylamide-co-acrylic acid) (PNIPAm-co-AAc) microgel-loaded polycaprolactone (PCL) nanofibers as temperature-, pH- and electro-responsive materials. First, the PNIPAm-co-AAc microgels were prepared by precipitation polymerization and then electrospun with PCL. The morphology of the prepared materials, analysed by scanning electron microscopy, showed a narrow nanofiber distribution in the range of 500–800 nm, depending on microgel content. Refractometry measurements, performed at pH 4 and 6.5, as well as in distilled water, indicated the thermo- and pH-responsive behaviour of the nanofibers between 31 and 34 °C. After being thoroughly characterized, the prepared nanofibers were loaded with crystal violet (CV) or gentamicin as model drugs. The application of a pulsed voltage led to a pronounced increase in drug release kinetics, which was also dependent on microgel content. In addition, long-term temperature- and pH-responsive release was demonstrated. Next, the prepared materials displayed switchable antibacterial activity against S. aureus and E. coli. Finally, cell compatibility tests showed that NIH 3T3 fibroblasts spread evenly over the nanofiber surface, confirming that the nanofibers serve as a favourable support for cell growth. Overall, the prepared nanofibers offer switchable drug release and appear to have considerable biomedical potential, particularly in wound healing.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
20501 - Materials engineering
Result continuities
Project
<a href="/en/project/GA21-06065S" target="_blank" >GA21-06065S: New functionalized plasmon-based sensors as tools for cell monitoring and advanced tissue engineering</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2023
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Journal of Colloid and Interface Science
ISSN
0021-9797
e-ISSN
1095-7103
Volume of the periodical
648
Issue of the periodical within the volume
15 October 2023
Country of publishing house
NL - THE KINGDOM OF THE NETHERLANDS
Number of pages
10
Pages from-to
338-347
UT code for WoS article
001017578100001
EID of the result in the Scopus database
2-s2.0-85161510466