Temperature-responsive PLLA/PNIPAM nanofibers for switchable release
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60461373%3A22310%2F17%3A43913993" target="_blank" >RIV/60461373:22310/17:43913993 - isvavai.cz</a>
Alternative codes found
RIV/60461373:22330/17:43913993
Result on the web
<a href="https://doi.org/10.1016/j.msec.2016.11.028" target="_blank" >https://doi.org/10.1016/j.msec.2016.11.028</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.msec.2016.11.028" target="_blank" >10.1016/j.msec.2016.11.028</a>
Alternative languages
Result language
angličtina
Original language name
Temperature-responsive PLLA/PNIPAM nanofibers for switchable release
Original language description
Smart antimicrobial materials with on-demand drug release are highly desired for biomedical applications. Herein, we report about temperature-responsive poly(N-isopropylacrylamide) (PNIPAM) nanospheres doped with crystal violet (CV) and incorporated into the poly-L-lactide (PLLA) nanofibers. The nanofibers were prepared by electrospinning, using different initial polymers ratios. The morphology of the nanofibers and polymers distribution in the nanofibers were characterized by scanning electron microscopy (SEM) and atomic forte microscopy (AFM). The interaction between PNIPAM and PLLA in the nanofibers was studied by Fourier transform infrared spectroscopy (FTIR) and its effect on the PNIPAM phase transition was also investigated. It was shown that by the changing of the environmental temperature across the lower critical solution temperature (LCST) of PNIPAM, the switchable wettability and controlled CV release can be achieved. The temperature-dependent release kinetics of CV from polymer nanofibers was investigated by ultraviolet-visible spectroscopy (UV-Vis). The temperature-responsive release of antibacterial CV was also tested for triggering of antibacterial activity, which was examined on Staphylococcus epidermidis (S. epidermidis) and Escherichia coli (E. coli). Thus, the proposed material is promising value for controllable drug-release.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
20501 - Materials engineering
Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2017
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Materials science and engineering C
ISSN
0928-4931
e-ISSN
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Volume of the periodical
72
Issue of the periodical within the volume
MAR 1 2017
Country of publishing house
NL - THE KINGDOM OF THE NETHERLANDS
Number of pages
8
Pages from-to
293-300
UT code for WoS article
000392165600035
EID of the result in the Scopus database
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