Imiquimod nanocrystal-loaded dissolving microneedles prepared by DLP printing
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60461373%3A22310%2F24%3A43929455" target="_blank" >RIV/60461373:22310/24:43929455 - isvavai.cz</a>
Alternative codes found
RIV/60461373:22340/24:43929455
Result on the web
<a href="https://link.springer.com/article/10.1007/s13346-024-01567-0" target="_blank" >https://link.springer.com/article/10.1007/s13346-024-01567-0</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1007/s13346-024-01567-0" target="_blank" >10.1007/s13346-024-01567-0</a>
Alternative languages
Result language
angličtina
Original language name
Imiquimod nanocrystal-loaded dissolving microneedles prepared by DLP printing
Original language description
The utilization of 3D printing- digital light processing (DLP) technique, for the direct fabrication of microneedles encounters the problem of drug solubility in printing resin, especially if it is predominantly composed of water. The possible solution how to ensure ideal belonging of drug and water-based printing resin is its pre-formulation in nanosuspension such as nanocrystals. This study investigates the feasibility of this approach on a resin containing nanocrystals of imiquimod (IMQ), an active used in (pre)cancerous skin conditions, well known for its problematic solubility and bioavailability. The resin blend of polyethylene glycol diacrylate and N-vinylpyrrolidone, and lithium phenyl-2,4,6-trimethylbenzoylphosphinate as a photoinitiator, was used, mixed with IMQ nanocrystals in water. The final microneedle-patches had 36 cylindrical microneedles arranged in a square grid, measuring approximately 600 mu m in height and 500 mu m in diameter. They contained 5wt% IMQ, which is equivalent to a commercially available cream. The homogeneity of IMQ distribution in the matrix was higher for nanocrystals compared to usual crystalline form. The release of IMQ from the patches was determined ex vivo in natural skin and revealed a 48% increase in efficacy for nanocrystal formulations compared to the crystalline form of IMQ.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
21001 - Nano-materials (production and properties)
Result continuities
Project
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Continuities
S - Specificky vyzkum na vysokych skolach
Others
Publication year
2024
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Drug Delivery and Translational Research
ISSN
2190-393X
e-ISSN
2190-3948
Volume of the periodical
neuveden
Issue of the periodical within the volume
2024
Country of publishing house
US - UNITED STATES
Number of pages
13
Pages from-to
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UT code for WoS article
001181257600001
EID of the result in the Scopus database
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