Nanocrystals for dermal penetration enhancement - Effect of concentration and underlying mechanisms using curcumin as model
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60461373%3A22340%2F16%3A43902089" target="_blank" >RIV/60461373:22340/16:43902089 - isvavai.cz</a>
Alternative codes found
RIV/60461373:22330/16:43902089
Result on the web
<a href="http://dx.doi.org/10.1016/j.ejpb.2016.05.004" target="_blank" >http://dx.doi.org/10.1016/j.ejpb.2016.05.004</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.ejpb.2016.05.004" target="_blank" >10.1016/j.ejpb.2016.05.004</a>
Alternative languages
Result language
angličtina
Original language name
Nanocrystals for dermal penetration enhancement - Effect of concentration and underlying mechanisms using curcumin as model
Original language description
Nanocrystals have received considerable attention in dermal application due to their ability to enhance delivery to the skin and overcome bioavailability issues caused by poor water and oil drug solubility. The objective of this study was to investigate the effect of nanocrystals on the mechanism of penetration behavior of curcumin as a model drug. Curcumin nanocrystals were produced by the smartCrystals? process, i.e. bead milling followed by high pressure homogenization. The mean particle size of the curcumin crystals was about 200 nm. Stabilization was performed with alkyl polyglycoside surfactants. The distribution of curcumin within the skin was determined in vitro on cross-sections of porcine skin and visualized by fluorescent microscopy. The skin penetration profile was analyzed for the curcumin nanosuspension with decreasing concentrations (2%, 0.2%, 0.02% and 0.002% by weight) and compared to nanocrystals in a viscous hydroxypropylcellulose (HPC) gel. This study demonstrated there was minor difference between low viscous nanosuspension and the gel, but low viscosity seemed to favor skin penetration. Localization of curcumin was observed in the hair follicles, also contributing to skin uptake. Looking at the penetration of curcumin from formulations with decreasing nanocrystal concentration, formulations with 2%, 0.2% and 0.02% showed a similar penetration profile, whereas a significantly weaker fluorescence was observed in the case of a formulation containing 0.002% of curcumin nanocrystals.
Czech name
—
Czech description
—
Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
CI - Industrial chemistry and chemical engineering
OECD FORD branch
—
Result continuities
Project
—
Continuities
S - Specificky vyzkum na vysokych skolach
Others
Publication year
2016
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
European Journal of Pharmaceutics and Biopharmaceutics
ISSN
0939-6411
e-ISSN
—
Volume of the periodical
104
Issue of the periodical within the volume
July 2016
Country of publishing house
US - UNITED STATES
Number of pages
10
Pages from-to
216-225
UT code for WoS article
000378662400023
EID of the result in the Scopus database
2-s2.0-84969545591