Solvatochromic Shift Enables Intracellular Fate Determination of Curcumin Nanocrystals

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60461373%3A22340%2F22%3A43924675" target="_blank" >RIV/60461373:22340/22:43924675 - isvavai.cz</a>
Result on the web
<a href="https://doi.org/10.1002/ppsc.202200115" target="_blank" >https://doi.org/10.1002/ppsc.202200115</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1002/ppsc.202200115" target="_blank" >10.1002/ppsc.202200115</a>

Result language
angličtina
Original language name
Solvatochromic Shift Enables Intracellular Fate Determination of Curcumin Nanocrystals
Original language description
Drug nanocrystals represent an effective way of delivering poorly water-soluble substances to target tissues and cells. Due to the large specific surface area, nanocrystals promote dissolution; therefore, the drug usually co-exists in both crystalline and dissolved forms. Commonly used analytical methods do not make it possible to easily distinguish between these forms within live cells. The present study reports a novel fluorescence microscopy method that makes it possible to distinguish intracellular forms of curcumin based on differences in fluorescence emission spectra. Due to solvatochromism, crystalline curcumin can be distinguished from curcumin dissolved in the lipidic components of cells. The methodology utilization is demonstrated by investigating the effect of surface stabilization of curcumin nanocrystals on cell uptake by different cell lines: macrophages and epithelial cells. The understanding of factors that control drug nanocrystal phagocytosis makes it possible to better interpret the observed anticancer effects of curcumin nanocrystals and design efficient drug delivery systems. © 2022 Wiley-VCH GmbH.
Czech name
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Czech description
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Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
21001 - Nano-materials (production and properties)

Project
<a href="/en/project/GX19-26127X" target="_blank" >GX19-26127X: The robotic nano-pharmacist: Next-generation manufacturing processes for personalised therapeutic agents</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year
2022
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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