Laser irradiation of human skin tissue after gold nanoparticles injection for thermal ablation processes – a combined experimental and numerical approach
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60461373%3A22310%2F25%3A43932496" target="_blank" >RIV/60461373:22310/25:43932496 - isvavai.cz</a>
Result on the web
<a href="https://www.nature.com/articles/s41598-025-17459-3" target="_blank" >https://www.nature.com/articles/s41598-025-17459-3</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1038/s41598-025-17459-3" target="_blank" >10.1038/s41598-025-17459-3</a>
Alternative languages
Result language
angličtina
Original language name
Laser irradiation of human skin tissue after gold nanoparticles injection for thermal ablation processes – a combined experimental and numerical approach
Original language description
In recent years, investigation of new or combined therapeutic modalities for cancer treatment lead to relevant scientific advances. Among these innovative therapeutic modalities photothermal therapy (PTT) attracts attention as an alternative or complementary possibility to current anti-cancer treatments as it allows for the selective ablation of cancer cells. In the present study, PTT is investigated by using gold nanoparticles (AuNPs) as photothermal transducers. AuNPs are injected into human skin and used for PTT-assisted tumor ablation. The effectiveness of the PTT is evaluated as a function of AuNPs morphology, dimensions and the wavelength of the laser source. Five different laser sources with wavelengths ranging from 465 to 980 nm are used. The experimental findings point out that 808 and 980 nm are the optimal laser wavelengths for the PTT of human skin. Especially gold nanorods stabilized by poly(ethylene glycol) layer are identified as effective photothermal transducers. The experimental results are fully corroborated by numerical calculations. The outcomes emphasize the potential and the relevance of synthetically tailoring AuNPs particularly in optimizing their optical properties and assessing the effects of AuNP aggregation for specific applications. © 2025 Elsevier B.V., All rights reserved.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10700 - Other natural sciences
Result continuities
Project
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Continuities
N - Vyzkumna aktivita podporovana z neverejnych zdroju
Others
Publication year
2025
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Scientific Reports
ISSN
2045-2322
e-ISSN
2045-2322
Volume of the periodical
15
Issue of the periodical within the volume
1
Country of publishing house
GB - UNITED KINGDOM
Number of pages
35
Pages from-to
34422
UT code for WoS article
001587018600015
EID of the result in the Scopus database
2-s2.0-105017645000