Sol-gel TiO2-based coatings in 3D printed porous Ti-6Al-4V alloy structures as efficient antibacterial drug delivery systems: Thorough structural and biological characterization

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60461373%3A22310%2F25%3A43933096" target="_blank" >RIV/60461373:22310/25:43933096 - isvavai.cz</a>

Alternative codes found

RIV/60461373:22330/25:43933096

Result on the web

<a href="https://www.sciencedirect.com/science/article/pii/S2666523925001242" target="_blank" >https://www.sciencedirect.com/science/article/pii/S2666523925001242</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.apsadv.2025.100816" target="_blank" >10.1016/j.apsadv.2025.100816</a>

Result language

angličtina

Original language name

Sol-gel TiO2-based coatings in 3D printed porous Ti-6Al-4V alloy structures as efficient antibacterial drug delivery systems: Thorough structural and biological characterization

Original language description

The application of sol-gel coatings on titanium-based materials offers a promising approach for enhancing their bioactivity, antibacterial properties, and adhesion, particularly for biomedical applications. This study focuses, for the first time, on the preparation and characterization of sol-gel TiO2-based coatings containing hydroxyapatite and silver in 3D-printed porous gyroid and dodethick structures. TiO2-based coatings on the standard wrought Ti-Al-V alloy rods were used as a reference. The coatings were applied via the specific dip-coating process developed by the author team. The microstructural analysis revealed that the sol-gel coatings on the reference wrought rod samples were homogeneous and well-adhered. The coatings on the porous gyroid and dodethick structures exhibited some localized cracking due to the complex geometry of the porous structures. Bioactivity was evaluated through the standard in vitro simulated body fluid tests, confirming hydroxyapatite precipitation on HA-containing coatings. Antibacterial properties were assessed against Escherichia coli, demonstrating nearly 100 % bacterial inhibition for Ag-containing coatings. Cytotoxicity tests with L929 fibroblast cells indicated that coatings with lower Ag concentrations in sol were non-toxic, while higher Ag concentrations in sol resulted in reduced cell viability, particularly in gyroid structures.

Czech name

—

Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

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OECD FORD branch

20500 - Materials engineering

Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2025

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Applied Surface Science Advances

ISSN

2666-5239

e-ISSN

—

Volume of the periodical

29

Issue of the periodical within the volume

September

Country of publishing house

NL - THE KINGDOM OF THE NETHERLANDS

Number of pages

14

Pages from-to

nestránkováno

UT code for WoS article

001552208600001

EID of the result in the Scopus database

2-s2.0-105013233738