Chiral separation and spectroscopic characterization of mefloquine analogues
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60461373%3A22310%2F25%3A43933880" target="_blank" >RIV/60461373:22310/25:43933880 - isvavai.cz</a>
Alternative codes found
RIV/60461373:22340/25:43933880
Result on the web
<a href="https://doi.org/10.1016/j.saa.2024.124940" target="_blank" >https://doi.org/10.1016/j.saa.2024.124940</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.saa.2024.124940" target="_blank" >10.1016/j.saa.2024.124940</a>
Alternative languages
Result language
angličtina
Original language name
Chiral separation and spectroscopic characterization of mefloquine analogues
Original language description
Mefloquine, a widely used antimalarial agent, has spurred ongoing research into the development of derivatives with enhanced efficacy and reduced side effects. In this investigation, we synthesized two compounds containing N-allyl or N-tert-butylacetamid groups. A chiral liquid chromatography with polysaccharide chiral stationary phase was utilized to separate the enantiomers of both derivatives. We employed spectroscopic chiroptical and non-polarizable methods such as electronic and vibrational circular dichroism, infrared absorption and ultraviolet spectroscopies. Combined with density functional theory calculations, the stable conformers were found in solution and their spectra were subsequently simulated. We elucidated the three-dimensional structure of the enantiomerically pure compounds and assigned the absolute configuration of all prepared derivatives using both experimental and simulated spectra.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
21100 - Other engineering and technologies
Result continuities
Project
<a href="/en/project/GC21-31139J" target="_blank" >GC21-31139J: Novel chiral ion-exchangers for chromatographic enantioseparations</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2025
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
ISSN
1386-1425
e-ISSN
1873-3557
Volume of the periodical
324
Issue of the periodical within the volume
5 January 2025
Country of publishing house
NL - THE KINGDOM OF THE NETHERLANDS
Number of pages
10
Pages from-to
nestránkováno
UT code for WoS article
001300347000001
EID of the result in the Scopus database
2-s2.0-85201634286