Transgenic Resistin Impair skeletal Muscle Glucose Metabolism in the Spontaneosly Hypertensive Rat
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60461373%3A22330%2F03%3A00008965" target="_blank" >RIV/60461373:22330/03:00008965 - isvavai.cz</a>
Result on the web
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DOI - Digital Object Identifier
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Alternative languages
Result language
angličtina
Original language name
Transgenic Resistin Impair skeletal Muscle Glucose Metabolism in the Spontaneosly Hypertensive Rat
Original language description
Increased serum levels of resistin, a molecule secreted by fat cells, have been proposed as a possible mechanistic link between obesity and insulin resistance. To further investigate the effects of resistin on glucose metabolism, we derived a novel transgenic strain of spontaneously hypertensive rats expressing the mouse resistin gene under the control of the fat-specific aP2 promoter and also performed in vitro studies of the effects of recombinant resistin on glucose metabolism in isolated skeletal muscle. Expression of the resistin transgene was detected by Northern blot analysis in adipose tissue and by real-time PCR in skeletal muscle and was associated with increased serum fatty acids and muscle triglycerides, impaired skeletal muscle glucose metabolism, and glucose intolerance in the absence of any changes in serum resistin concentrations. In skeletal muscle isolated from non-transgenic spontaneously hypertensive rats, in vitro incubation with recombinant resistin significantly
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
CE - Biochemistry
OECD FORD branch
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Result continuities
Project
<a href="/en/project/GA301%2F03%2F0751" target="_blank" >GA301/03/0751: Transgenic analysis of the resistin effects on cyrbohydrate and lipid metabolism in spontaneously hypertensive rats</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2003
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
The Journal of biological chemistry
ISSN
0021-9258
e-ISSN
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Volume of the periodical
278
Issue of the periodical within the volume
46
Country of publishing house
US - UNITED STATES
Number of pages
7
Pages from-to
45209-15
UT code for WoS article
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EID of the result in the Scopus database
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