Development of an enzyme immunoassay for the determination of isoflavones

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60461373%3A22330%2F04%3A00012767" target="_blank" >RIV/60461373:22330/04:00012767 - isvavai.cz</a>
Result on the web
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DOI - Digital Object Identifier
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Result language
angličtina
Original language name
Development of an enzyme immunoassay for the determination of isoflavones
Original language description
Isoflavones are plant secondary metabolites typical for leguminous plants, however they were found also in certain non-leguminous taxa. Isoflavones were reported to display a wide scale of biological effects in plant-consuming animals including humans. They are endocrinologicaly active due to interaction with estrogen receptors and due to modulation of several hormonogenic metabolic pathways. Genistein is well known inhibitor of tyrosine-protein kinases - the enzymes acting in post-receptor events of peptide hormone signaling. Dietary isoflavones have been reported protective against several types of neoplasias, cardiovascular diseaeses and menopausal symtoms. Enzyme-linked immunosorbent assays (ELISAs) were developed for determination of the most important isoflavones - i.e. genistein, daidzein and biochanin A in biological materials. The indirect competitive ELISA format uses polyclonal rabbit antibodies formed against conjugates of carboxymethyl isoflavones with bovine serum albumin
Czech name
Vývoj enzymové imunoanalýzy pro detekci isoflavonů
Czech description
Vývoj enzymové imunoanalýzy pro detekci isoflavonů

Publication year
2004
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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