Novel perfluoroalkytated derivatives of D-galactopyranose and xylitol for biomedical uses. Hemocompatibility and effect on perfluorocarbon emulsions.

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60461373%3A22330%2F04%3A00012848" target="_blank" >RIV/60461373:22330/04:00012848 - isvavai.cz</a>

Result on the web

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DOI - Digital Object Identifier

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Result language

angličtina

Original language name

Novel perfluoroalkytated derivatives of D-galactopyranose and xylitol for biomedical uses. Hemocompatibility and effect on perfluorocarbon emulsions.

Original language description

6-O-(4,4,5,5,6,6,7,7,7-Nonafluoro-2-hydroxyheptyl)-, 6-O-(4,4,5,5,6,6,7,7,8,8,9,9,9-tridecafluoro-2-hydroxynonyl)-, and 6-O-(4,4,5,5,6,6,7,7,8,8,9,9,10,10,11,11,11-heptadecafluoro-2-hydroxyundecyl)-D-galactopyranose were prepared by a two-step synthesisfrom 1,2:3,4-di-O-isopropylidene-a-D-galactopyranose and 2-[(perfluoroalkyl) methyl]oxiranes under catalysis with BF3/Et2O. Similarly, 1-O-(4,4,5,5,6,6,7,7,7-nonafluoro-2-hydroxyheptyl)-, 1-O-(4,4,5,5,6,6,7,7,8,8,9,9,9-tridecafluoro-2-hydroxynonyl)-, 1-O-(4,4,5,5,6,6,7,7,8,8,9,9,10,10,11,11,11-heptadecafluoro-2-hydroxyundecyl)-DL-xylitol were prepared from 1,2:3,4-di-O-isopropylidene-DL-xylitol. Most of the compounds displayed very low level of hemolytic activity and excellent co-emulsifying propertieson testing on perfluorodecalin-Pluronic F-68 microemulsions.

Czech name

Nové pefluoralkylované deriváty D-galaktopyranosy a xylitolu pro biomedicinální použití. Hemokompatibilita a vliv na emulze perfluoruhlovodíků.

Czech description

6-O-(4,4,5,5,6,6,7,7,7-Nonafluor-2-hydroxyheptyl)-, 6-O-(4,4,5,5,6,6,7,7,8,8,9,9,9-tridekafluor-2-hydroxynonyl)-, and 6-O-(4,4,5,5,6,6,7,7,8,8,9,9,10,10,11,11,11-heptadekafluor-2-hydroxyundecyl)-D-galaktopyranosy byly připraveny reakcí 1,2:3,4-di-O-isopropylidene-a-D-galagtopyranosy s 2-[(perfluoralkyl) methyl]oxirany za katalýzy BF3/Et2O. 1-O-(4,4,5,5,6,6,7,7,7-Nonafluor-2-hydroxyheptyl)-, 1-O-(4,4,5,5,6,6,7,7,8,8,9,9,9-tridekafluor-2-hydroxynonyl)-, 1-O-(4,4,5,5,6,6,7,7,8,8,9,9,10,10,11,11,11-heptadecafluoro-2-hydroxyundecyl)-DL-xylitoly byly připraveny z 1,2:3,4-di-O-isopropylidene-DL-xylitolu. Většina látek měla nízkou hemolytickou aktivitu a byly výborné emulgátory.

Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

CC - Organic chemistry

OECD FORD branch

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Project

<a href="/en/project/GA203%2F01%2F1311" target="_blank" >GA203/01/1311: New generation of compounds for blood substitutes and other medicinal applications</a><br>

Continuities

Z - Vyzkumny zamer (s odkazem do CEZ)

Publication year

2004

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Carbohydrate Research

ISSN

0008-6215

e-ISSN

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Volume of the periodical

Neuveden

Issue of the periodical within the volume

339

Country of publishing house

BE - BELGIUM

Number of pages

9

Pages from-to

2177-2185

UT code for WoS article

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EID of the result in the Scopus database

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