CZE separation of enantiomers of lisuride

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60461373%3A22330%2F05%3A00016006" target="_blank" >RIV/60461373:22330/05:00016006 - isvavai.cz</a>
Result on the web
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DOI - Digital Object Identifier
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Result language
angličtina
Original language name
CZE separation of enantiomers of lisuride
Original language description
Lisuride is an ergot alkaloid derivative with dopaminergic activity. It is used for treatment of Parkinsonism and some other diseases associated with high level of prolactine. Lisuride is a chiral compound derived from natural ergot alkaloids. A new capillary zone electrophoresis (CZE) method capable of separating the enantiomers of lisuride was developed. Using the optimized conditions (acidic electrolyte with the addition of gamma-cyclodextrin ( -CD)) as low as 0.02% of undesirable l-lisuride can be detected. Selected method characteristics, i.e., linearity (0#20 mg/l), precision (2.0% at 5 mg/l), and accuracy (101#4% at 5 mg/l) were evaluated. The optimized method was applied for the analysis of real batches of Lisuride hydrogenmaleate and Lisuridebase manufactured by IVAX Pharmaceuticals. It was found that they contain lessthan 0.02% of undesirable l-enantiomer.
Czech name
CZE separace enentiomerů lisuridu
Czech description
CZE separace enentiomerů lisuridu

Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
GM - Food industry
OECD FORD branch
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Project
<a href="/en/project/GA525%2F03%2F0351" target="_blank" >GA525/03/0351: Application of capillary electrophoresis for analysis of bioactive compounds in food</a><br>
Continuities
Z - Vyzkumny zamer (s odkazem do CEZ)

Publication year
2005
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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