The role of protein CD36 as an important risc factor of cardiovascular diseases

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60461373%3A22330%2F06%3A00017207" target="_blank" >RIV/60461373:22330/06:00017207 - isvavai.cz</a>

Result on the web

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DOI - Digital Object Identifier

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Result language

čeština

Original language name

Role proteinu CD36 jako vyznamneho rizikoveho faktoru kardiovaskularnich onemocneni

Original language description

The human essential hypertension syndrom (syndrom X) including also hyperlipidemia and insulin resistence is a cluster of metabolic disorders whose molecular basis is largely unknown. The most widely studied animal model of hypertension is a Spontaneously Hypertensive Rat (SHR). To identify chromosome region contributing to this clustering of cardiovascular risk factors in the SHR was searched for quantitative trait loci (QTL) associated with insulin resistance, glucose intolerance and dyslipidemia by using recombinant inbred strain. Spontaneously Hypertensive Rat (SHR) displays many of the features of human metabolic disease syndroms thus SHR can be used as a model of mutation in CD36 and study of its protein. Protein CD36 is known as a receptor for thrombospondin-1 and collagen. It also functions as a signal transduction molecule, main glycoprotein of adipocytes and muscle cells, binds long chain fatty acids and functions in their transport through the membrane. CD36 on monocytes and

Czech name

Role proteinu CD36 jako vyznamneho rizikoveho faktoru kardiovaskularnich onemocneni

Czech description

The human essential hypertension syndrom (syndrom X) including also hyperlipidemia and insulin resistence is a cluster of metabolic disorders whose molecular basis is largely unknown. The most widely studied animal model of hypertension is a Spontaneously Hypertensive Rat (SHR). To identify chromosome region contributing to this clustering of cardiovascular risk factors in the SHR was searched for quantitative trait loci (QTL) associated with insulin resistance, glucose intolerance and dyslipidemia by using recombinant inbred strain. Spontaneously Hypertensive Rat (SHR) displays many of the features of human metabolic disease syndroms thus SHR can be used as a model of mutation in CD36 and study of its protein. Protein CD36 is known as a receptor for thrombospondin-1 and collagen. It also functions as a signal transduction molecule, main glycoprotein of adipocytes and muscle cells, binds long chain fatty acids and functions in their transport through the membrane. CD36 on monocytes and

Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

CE - Biochemistry

OECD FORD branch

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Project

<a href="/en/project/GA301%2F03%2F0751" target="_blank" >GA301/03/0751: Transgenic analysis of the resistin effects on cyrbohydrate and lipid metabolism in spontaneously hypertensive rats</a><br>

Continuities

Z - Vyzkumny zamer (s odkazem do CEZ)

Publication year

2006

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Chemické listy

ISSN

0009-2770

e-ISSN

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Volume of the periodical

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Issue of the periodical within the volume

100

Country of publishing house

CZ - CZECH REPUBLIC

Number of pages

7

Pages from-to

17-23

UT code for WoS article

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EID of the result in the Scopus database

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