ELISA estimation of S-equol in human body fluids

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60461373%3A22330%2F10%3A00024177" target="_blank" >RIV/60461373:22330/10:00024177 - isvavai.cz</a>
Result on the web
—
DOI - Digital Object Identifier
—

Result language
angličtina
Original language name
ELISA estimation of S-equol in human body fluids
Original language description
Equol is a biologically active metabolite of isoflavonoid daidzein, which is the principle of food supplements designated for women in climacterium. The conversion from daidzein to equol is caused by the intestinal microflora. Therefore this microflora differs bethween individuals, the production of equol isn?t uniform. Equol is a chiral molecule. Always S-equol rise by the action of intestinal microflora in human body, R-equol was prepared only synthetically. S-equol acts as a weak agonist in estrogenreceptors ? and therefore is in many cases a good alternative to hormone replacement therapy. The object of this study was to optimize the competitive enzyme-liked immunosorbent assay (ELISA) method for the determination of equol in human body fluids using enantiometrically pure standards. Racemic equol conjugates coupled to bovine serum albumine at positions 4'-O- via carboxymethyl spacer were used as immunogens. Conjugates of the same hapten with ovalbumine were used for coating of the
Czech name
—
Czech description
—

Project
<a href="/en/project/GA303%2F08%2F0958" target="_blank" >GA303/08/0958: Phytoestrogens as an Alternative to Hormone Replacement Therapy - An Efficiency and Safety Study</a><br>
Continuities
Z - Vyzkumny zamer (s odkazem do CEZ)

Publication year
2010
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Similar results(10)