Larvae of fleshfly Neobellieria bullata as a source for novel antimicrobial peptides

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60461373%3A22330%2F11%3A43892576" target="_blank" >RIV/60461373:22330/11:43892576 - isvavai.cz</a>
Result on the web
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DOI - Digital Object Identifier
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Result language
angličtina
Original language name
Larvae of fleshfly Neobellieria bullata as a source for novel antimicrobial peptides
Original language description
The resistant strains of microorganisms are increasing threat for public health. Antimicrobial peptides from natural sources display a wide spectrum of activity. In our lab several peptide fraction with antimicrobial acivity against grampositive and gramnegative bacteria and fungi from larvae of fleshfly Neobellieria bullata were isolated. Presence of peptides was proved by tricine electrophoresis, molecular weights and sequences were determined by MS and N-terminal Edman sequencing. In comparison withdatabase sequences we obtained structures present in mainly insect and amphibian antimicrobial peptides, but total matches were not corresponding more than in 36%. Upon the obtained sequence motifs we designed structures of several synthetic peptides. These were synthetised on the Rink amide MBHA resin. Synthesis was performed according Fmoc/PyBOP-DIEA protocol. Activity of these peptides was determined.
Czech name
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Czech description
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Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>Z - Vyzkumny zamer (s odkazem do CEZ)

Publication year
2011
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Article name in the collection
Collection Symposium Series: Biologically Active Peptides
ISBN
978-80-86241-44-9
ISSN
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e-ISSN
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Number of pages
3
Pages from-to
100-102
Publisher name
Ústav organické chemie a biochemie AV ČR
Place of publication
Praha
Event location
Praha
Event date
Apr 27, 2011
Type of event by nationality
EUR - Evropská akce
UT code for WoS article
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