Investigation of substituted 6-aminohexanoates as skin penetration enhancers

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60461373%3A22330%2F12%3A43892403" target="_blank" >RIV/60461373:22330/12:43892403 - isvavai.cz</a>

Alternative codes found

RIV/62157124:16370/12:43871111

Result on the web

<a href="http://dx.doi.org/10.1016/j.bmc.2011.11.033" target="_blank" >http://dx.doi.org/10.1016/j.bmc.2011.11.033</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.bmc.2011.11.033" target="_blank" >10.1016/j.bmc.2011.11.033</a>

Result language

angličtina

Original language name

Investigation of substituted 6-aminohexanoates as skin penetration enhancers

Original language description

Skin penetration enhancers are compounds used to facilitate the transdermal delivery of drugs that are otherwise not sufficiently permeable. Through a synthetic route implementing two series of esters, we generated transdermal penetration enhancers by amulti-step reaction with substituted 6-aminohexanoic acid. We present the synthesis of all newly prepared compounds here with structural confirmation accomplished by 1H NMR, 13C NMR, IR and mass spectroscopy (MS). The lipophilicity (logk) of all compounds was determined via RP-HPLC and their hydrophobicity (logP/ClogP) was also calculated using two commercially available programs. Ab initio calculations of geometry and molecular dynamic simulations were employed to investigate the 3-dimensional structures of selected compounds. The transdermal penetration-enhancing activity of all the synthesized esters were examined in vitro and demonstrated higher enhancement ratios than oleic acid. Compounds 2e (C10 ester chain) and 2f (C11 ester cha

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

CC - Organic chemistry

OECD FORD branch

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Project

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Continuities

Z - Vyzkumny zamer (s odkazem do CEZ)

Publication year

2012

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

BIOORGANIC & MEDICINAL CHEMISTRY

ISSN

0968-0896

e-ISSN

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Volume of the periodical

20

Issue of the periodical within the volume

1

Country of publishing house

GB - UNITED KINGDOM

Number of pages

10

Pages from-to

86-95

UT code for WoS article

000298633300008

EID of the result in the Scopus database

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