Investigation of new acyloxy derivatives of cholic acid and their esters as drug absorption modifiers
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15310%2F11%3A33118174" target="_blank" >RIV/61989592:15310/11:33118174 - isvavai.cz</a>
Alternative codes found
RIV/61389030:_____/11:00368601 RIV/60461373:22340/11:43891794 RIV/60461373:22330/11:43891794 RIV/62157124:16370/11:43870800
Result on the web
<a href="http://dx.doi.org/10.1016/j.steroids.2011.04.014" target="_blank" >http://dx.doi.org/10.1016/j.steroids.2011.04.014</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.steroids.2011.04.014" target="_blank" >10.1016/j.steroids.2011.04.014</a>
Alternative languages
Result language
angličtina
Original language name
Investigation of new acyloxy derivatives of cholic acid and their esters as drug absorption modifiers
Original language description
Skin penetration enhancers are used in the formulation of transdermal delivery systems for drugs that are otherwise not sufficiently skin-permeable. Intestinal absorption promoters/enhancers are used as excipients in oral formulations of poorly oral-bioavailable drugs. Series of fourteen acyloxy derivatives of 5 beta-cholic acid as potential drug absorption modifiers was generated by multistep synthesis. The synthesis of all newly prepared compounds is presented here. Structure confirmation of all generated compounds was accomplished by (1)H NMR, (13)C NMR, IR and MS spectroscopy methods. All the prepared compounds were analyzed using RP-TLC, and their lipophilicity (R(M)) was determined. The hydrophobicity (log P) and solubility (logS) of the studiedcompounds were also calculated using two commercially available programs.
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
ED - Physiology
OECD FORD branch
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Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2011
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Steroids
ISSN
0039-128X
e-ISSN
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Volume of the periodical
76
Issue of the periodical within the volume
10
Country of publishing house
US - UNITED STATES
Number of pages
16
Pages from-to
1082-1097
UT code for WoS article
000294074700019
EID of the result in the Scopus database
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