New polyfluorothiopropanoyloxy derivatives of 5 beta-cholan-24-oic acid designed as drug absorption modifiers

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15310%2F13%3A33148057" target="_blank" >RIV/61989592:15310/13:33148057 - isvavai.cz</a>
Alternative codes found
RIV/62157124:16370/13:43872230 RIV/60461373:22340/13:43895075 RIV/60461373:22330/13:43895075 RIV/60461373:22810/13:43895075
Result on the web
<a href="http://www.sciencedirect.com/science/article/pii/S0039128X13001220" target="_blank" >http://www.sciencedirect.com/science/article/pii/S0039128X13001220</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.steroids.2013.05.012" target="_blank" >10.1016/j.steroids.2013.05.012</a>

Result language
angličtina
Original language name
New polyfluorothiopropanoyloxy derivatives of 5 beta-cholan-24-oic acid designed as drug absorption modifiers
Original language description
A series of final six propanoyloxy derivatives of 5 beta-cholan-24-oic acid (tridecafluoroctylsulfanyl- and tridecafluoroctylsulfinylethoxycarbonylpropanoyloxy derivatives) as potential drug absorption promoters (skin penetration enhancers, intestinal absorption promoters) was generated by multistep synthesis. Structure confirmation of all generated compounds was accomplished by H-1 NMR, C-13 NMR, IR and MS spectroscopy methods. All the prepared compounds were analyzed using RP-TLC, and their lipophilicity (R-M) was determined. The hydrophobicity (log P), solubility (log S), polar surface area (PSA) and molar volume (MV) of the studied compounds were also calculated. All the target compounds were tested for their in vitro transdermal penetration effectand as potential intestinal absorption enhancers. The cytotoxicity of all the evaluated compounds was evaluated against normal human skin fibroblast cells. Their anti-proliferative activity was also assessed against human cancer cell lin
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FR - Pharmacology and apothecary chemistry
OECD FORD branch
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Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year
2013
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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